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390-420 / 1000+ resultscommunity RCT: Rosemary-lavender oil formulation shown to stimulate hair growth when compared to placebo (2025)
Rosemary-lavender oil can stimulate hair growth compared to a placebo. Some users combine it with treatments like dutasteride, minoxidil, and RU58841.
community What new hair-loss treatments actually look exciting right now (Oct 2025)
New hair loss treatments include Breezula, PP405, ET-02, KX-826, GT20029, VDPHL01, and CosmeRNA, with some showing promise in reactivating stem cells and reversing greying. Breezula and VDPHL01 are highlighted as potential add-ons or alternatives to current treatments like finasteride and minoxidil.
community When should we get the next news about PP405
Results for PP405 are expected next year, with concerns about its pricing and potential black market availability. Some users believe it may be slightly more effective than finasteride and dutasteride, and combining it with treatments like minoxidil and microneedling could be beneficial.
community A non-responder revisiting Minoxidil with Follica FR5 / FR10 / FR15
The user discusses using Follics FR5, FR10, and FR15, which combine Minoxidil, Adenosine, Procapil, Azelaic acid, and Procyanidin B2, to address hair loss. They have previously used Minoxidil, Finasteride, and Dutasteride with varying success.
community I hope ET-02 or PP405 will be released in the next 4-5 years
PP405 is a potential hair loss treatment that may work by blocking signals that cause hair cells to stop growing, requiring daily application for effectiveness. It could serve as an alternative to minoxidil and finasteride, but it is not yet available on the market and may take several years to be released.
community peptides seems to have dramatically decreased hairloss!
Peptides like GHK-Cu, BPC-157, and TB-500 have significantly reduced hair loss, with GHK-Cu being particularly effective. The discussion also covers the high cost of these peptides and explores more affordable purchasing options.
community Does anybody use this? (Petal Fresh Hair ResQ shampoo)
Petal Fresh Hair ResQ shampoo is discussed for hair loss, with skepticism about its effectiveness. Minoxidil is mentioned as part of a treatment plan, and other recommended ingredients include Piroctone Olamine, Ketoconazole, and Saw Palmetto.
community Personal experience with Procyanidin B2
Personal experience with Procyanidin B2 shows it's ineffective for hair loss. Viviscal Pro supplement tablets, containing Procyanidin B2, didn't help after 8 months of use.
community Herbacle hair growth serum with 0% min
The conversation discusses the effectiveness of a new hair growth serum called HERBACLE, which claims to be the world's first, but lacks reviews and is doubted by users. One user notes that its ingredients are similar to those in The Ordinary's Multi-Peptide Serum for Hair Density.
community Update for PP405 - phase 2b underway
PP405 is advancing to Phase 2b trials, showing promise from Phase 2a. It may be available in 3-6 years, with trials using a topical gel.
community Oral minoxidil and lowering the dose?
The user is experiencing significant hair regrowth with 5 mg oral minoxidil and 1 mg finasteride but also side effects like eye puffiness and hypertrichosis. They are considering reducing the minoxidil dose to 2.5 mg to lessen side effects and are curious about caffeine serums for eye puffiness.
community (Topic) does saw palmetto actually work?
Saw palmetto can help reduce DHT levels and may work in combination with other supplements like beta sitosterol and pygume, but it's less effective than finasteride. Additional treatments like pumpkin seed extract, zinc, biotin, essential oils, scalp massages, and micro-needling can support hair health, but should not replace existing treatments like finasteride.
community Have any of you taken Pumpkin Seed Oil long term?
Pumpkin seed oil may help maintain hair and improve the crown area. Head massages are also considered beneficial.
community Before and after pics 3.5 months apart
The conversation discusses hair regrowth treatments, including stem cell exosomes, PRP, and PP405. Users question the effectiveness of the treatments and mention finasteride and minoxidil.
community ABS-201 KOL Seminar: Dr. Ralf Paus on Human Ex Vivo Hair Regrowth Data
ABS-201 shows promise for male hair regrowth by blocking the prolactin receptor, with higher expected efficacy than current treatments. The discussion also covers dosing differences between macaques and humans for hmi115, highlighting a significant dosage disparity.
community RU58841 longterm use and expectations.
community Finasteride topical formulation (pharmacy vs stemoxydine)
Hair loss discussion includes treatments like hinoki tree oil and procyanidin b2. Experiences and effectiveness of these treatments are shared.
community Can pp405 revive dead follicles for long time bald people? Are those even dead? After 10+ years bald
PP405 may revive dormant hair follicles but is unlikely to help with long-term baldness where follicles are replaced by scar tissue. It is seen as a potential adjunct to treatments like minoxidil and finasteride, but its effectiveness on deeply fibrotic or scarred areas is doubtful.
community Ghk-cu + c60 + saw palmetto oil
The conversation discusses using GHK-Cu, C60, and saw palmetto oil as treatments for hair loss. Specific treatments mentioned include Minoxidil (Min), Finasteride (Fin), and RU58841 (RU).
community If PP405 does revive "dead" hair follicles would DHT blockers theoretically be enough to maintain that new hair
PP405 may revive dormant hair follicles, and DHT blockers like finasteride or dutasteride could maintain new hair. Combining PP405 with minoxidil might be optimal, but long-term effects and continuous use are uncertain.
community Topical quercetin combined with finasteride for max results
Combining Finasteride with topical Quercetin, Onion/Garlic juice and Peppermint Oil to reduce Wet Prostate Weight in Rats. Luke10191 asked the user LITUATUI to update them on progress after trying this combination of treatments for hair loss.
community JXL082 is not PP405 and Everychem followed the wrong lead
JXL082 is not the same as PP405, leading to a halt in sales and a plan to synthesize the real PP405. There is skepticism about the safety and effectiveness of JXL082 and PP405, with concerns about patent issues and the long-term impact on hair growth.
community Pelage are going to do two phase 3 trials for PP405. How long will it take to complete two phase 3 trials?
Pelage plans to conduct two Phase 3 trials for PP405, a new hair loss treatment, which may take about a year to complete. Users discuss various hair loss treatments, including pyrilutamide, minoxidil, finasteride, and clascoterone, with some expressing impatience over the lengthy trial process compared to faster drug approvals like the COVID vaccine.
community Is there new research about pumpkin oil as a DHT blocker (2026)?
Pumpkin seed oil is considered a weak DHT blocker compared to finasteride and dutasteride, with some users reporting side effects like mood changes and reduced libido. Despite some anecdotal benefits for urinary issues, it is not effective for hair loss, and finasteride is preferred by some users for its lack of side effects.
community Any UK sources for minoxidil+RU58841 solution together? That doesn’t contain PG?
A user is seeking a UK source for a combined minoxidil and RU58841 solution that doesn't contain scalp-irritating ingredients. They specifically want a product without propylene glycol (PG).
community SCUBE3/Pyr/or anything else of interest in the piplines. any updates?
Hair loss treatments discussed include promising Pyr available online and Verteporfin dosing after FUE for follicle regeneration, but no updates on SCUBE3.
community Coegin Pharma to release Follicopeptide (FOL005) by Q2 2025
Follicopeptide (FOL005) by Coegin Pharma will launch as a cosmetic hair growth treatment by Q2 2025, showing similar efficacy to finasteride. Users discuss the benefits and skepticism of releasing hair loss treatments as cosmetics rather than drugs.
community Topical rapamycin, metformin, a-kg grow hair
The conversation discusses the potential of topical rapamycin, metformin, and alpha-ketoglutarate (a-KG) for hair growth, with skepticism expressed about their effectiveness based on personal experience and existing use. It also mentions AICAR, known as cardarine or GW, which is not suitable for long-term use due to cancer risks in animal studies and its similarity to metformin.
community Who else is looking forward to full phase 2 results of PP405?
PP405 is a potential hair loss treatment showing promise, especially for men with severe balding. Some are hopeful it will be a game-changer for those who cannot tolerate finasteride or minoxidil, despite skepticism about the outcomes.