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GlossaryProxalutamide

experimental drug blocking male hormone effects

Proxalutamide is an experimental drug that acts as a nonsteroidal antiandrogen, meaning it blocks the effects of androgens (male hormones) like testosterone. It is being studied for its potential use in treating conditions like prostate cancer and androgenetic alopecia (a common form of hair loss), by inhibiting the androgen receptors that contribute to these conditions.

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community Reminder that Kintors Pyrilutamide results will be out this month

in Treatment 176 upvotes 4 years ago

Kintor's Pyrilutamide results for hair loss treatment will be released soon. The treatment may replace current treatments like finasteride and minoxidil without systemic side effects.

community No side effects on pyrilutamide / KX-826 so far

in Research/Science 208 upvotes 4 years ago

User TopBack56 and friends tried pyrilutamide (KX-826) for hair loss without experiencing negative side effects. They observed fine vellus hairs but no thick hair growth yet, and plan to add GT20029 to their regime after safety trials.

community Anyone else just waiting until the real pyrilutamide and then GT20029?

in Chat 4 upvotes 2 years ago

The user is hesitant to use finasteride due to potential hormonal side effects and is waiting for the release of pyrilutamide, a new hair loss treatment. Other users suggest trying finasteride, warning about potential regret if hair loss progresses in the meantime.

community pyrilutamide solution progress log

in Product 20 upvotes 3 years ago

A 28 year old using a hair loss prevention protocol to restore thinning hair, which includes finasteride, dutasteride, minoxidil, stemoxydine, alopecin, nizoral shampoo and microneedling; the user is now adding pyrilutamide solution to the regimen with the hope of improving their results. RU58841 was also ordered but not yet used.

community Pyrilutamide for non-5AR users?

in Treatment 10 upvotes 1 year ago

Pyrilutamide is considered by some as an alternative for those avoiding 5AR inhibitors like finasteride and dutasteride, but opinions on its effectiveness vary. Some users report similar results with fluridil and pyrilutamide, while others find pyrilutamide less effective compared to prescription treatments.

community Binding affinity of pyrilutamide!

in Update 169 upvotes 3 years ago

Pyrilutamide, a nonsteroidal antiandrogen drug under development for the potential treatment of androgenic alopecia. The conversation discusses its binding affinity to the androgen receptor and the timeline for possible availability after trials are completed in the United States and China.

community pyrilutamide phase 2 results right here, thanks to user Glaringbooch

in Chat 45 upvotes 3 years ago

Pyrilutamide, a new drug being tested to combat hair loss that has been found to perform comparably or better than finasteride and dutasteride in the initial 6 months of treatment with minimal reported side effects.

community What happened to Pyrilutamide?

in Technology 1 upvotes 1 year ago

Pyrilutamide's 0.5% solution showed minimal improvement, while the 1% solution appears more promising but costly. The user is currently using finasteride and oral minoxidil and considering adding Pyrilutamide if effective and affordable.

community I'm very skeptical about pyrilutamide

in Product 2 upvotes 1 month ago

Pyrilutamide's effectiveness is questioned due to overstated claims and previous trial ineffectiveness, with some users opting for finasteride instead. Despite skepticism, some consider adding pyrilutamide to their regimen alongside treatments like bicalutamide.

community Anagen is now selling pyrilutamide

in Product 136 upvotes 3 years ago

Pyrilutamide, a potential hair loss treatment that has recently been released for sale, and is thought to have similar efficacy to Dutasteride without side effects. It was discussed in terms of its effectiveness compared to Finasteride, its use by females, and whether it can be safely mixed with RU58841.

community pyrilutamide log from someone who couldnt take fin/min/ru due to sideeffects

in Progress Pictures 101 upvotes 3 years ago

A user (seblt) who has had side effects from finasteride, minoxidil and RU58841 but is now trying pyrilutamide as a last resort, with other users providing advice and support. They have already seen some baby hairs growing after 10-14 days of treatment and will provide updates in 1-2 weeks.

community Pyrilutamide and RU alternatives?

in Treatment 1 upvotes 1 year ago

Pyrilutamide is officially available for purchase, and users suggest Fluridil as an alternative topical anti-androgen. Some users report positive results with pyrilutamide from Koshine.

community Pyrilutamide (KX-826) progress?

in Is this regrowth? 20 upvotes 1 year ago

The user has been using pyrilutamide 0.5% for over 7 weeks, alongside dutasteride, and noticed some hair improvement, particularly at the temples. They plan to continue and possibly try a 1% solution, with no shedding or side effects reported.

community Has anyone got results from pyrilutamide?

in Research/Science 3 upvotes 3 months ago

The user maintained hair with minoxidil, alfatradiol, and fluridil after stopping finasteride due to erectile dysfunction. They recently added pyrilutamide and are seeking feedback on its effectiveness after six months of use.

community Pyrilutamide ,the molecule’s true nature

in Research 302 upvotes 1 year ago

Pyrilutamide is a selective AR antagonist with a high binding affinity, making it effective in competing with DHT for androgen receptors. The 1% concentration is more effective than the 0.5%, but the latter may suffice for mild hair loss; the drug is considered a good option for those avoiding 5AR blockers due to side effects.

community [Research] RU-58841/Pyrilutamide and impacts on male fertility

in Research/Science 4 upvotes 2 years ago

The drugs RU-58841, Pyrilutamide (KX-826), Apalutamide, Enzalutamide, and Darolutamide, which are nonsteroidal antiandrogens (NSAA), potentially impacting male fertility. Pyrilutamide, similar to Enzalutamide, may have reversible effects on fertility.

community Pyrilutamide - Worth it if can’t use Fin?

in Research/Science 5 upvotes 10 months ago

Pyrilutamide is being discussed as an alternative for those who can't use finasteride, but users report it may be ineffective at low concentrations. Some users are combining it with minoxidil, microneedling, and other treatments, but results vary.

community pyrilutamide GB update please? Anything no matter how big or small

in Update 33 upvotes 3 years ago

The effects of Finasteride on hair loss and its side-effects, such as aching balls. The user has been taking it for two years with no changes to the symptom.

community Pyrilutamide almost for 9 months

in Progress Pictures 62 upvotes 2 years ago

The user has been using pyrilutamide, topical finasteride, and 15% minoxidil for hair growth for almost 4 years. Despite mixed responses from others, the user reports seeing progress, especially with the addition of pyrilutamide, and plans to continue the regimen.

community What’s the update on Pyrilutamide?

in Chat 12 upvotes 3 years ago

Pyrilutamide is seen as a last hope for those who can't take finasteride, with promising results reported. However, there's uncertainty about the quality and consistency of Pyrilutamide from black market sources.

community KX-826 Pyrilutamide1% coming soon

in Update 152 upvotes 1 year ago

KX-826 Pyrilutamide 1% is launching soon, and users are discussing its potential benefits and drawbacks compared to other treatments like Minoxidil and finasteride. Some users are skeptical about its effectiveness, while others are hopeful it will be a safer alternative.

community Is it safe to take oral dutasteride with pyrilutamide?

in Finasteride/Dutasteride 2 upvotes 5 months ago

It's safe to take oral dutasteride with pyrilutamide, as many use 5-alpha-reductase inhibitors with topical antiandrogens for better results. Avoid ingesting pyrilutamide.

community How to choose between topical antiandrogen (Pyrilutamide) vs topical Alfatradiol (17α-estradiol) as an add-on treatment?

in Treatment 6 upvotes 5 months ago

The user is considering adding Pyrilutamide or Alfatradiol as a topical treatment for hair loss after oral Finasteride and Dutasteride became less effective. Other users suggest Pyrilutamide for its safety profile, while one user shares positive experiences with RU58841 for reducing scalp itch and improving hairline.

community Earliest we can get legitimate pyrilutamide

in Research/Science 48 upvotes 3 years ago

Pyrilutamide, a drug in phase 3 trials in China, potentially becoming available in late 2023 or early 2024; Finasteride being used as a current treatment for hair loss; and the possibility of joining a group buy for black market versions of Pyrilutamide.

community Starting Pyrilutamide tomorrow. Will keep everyone updated

in Research/Science 176 upvotes 3 years ago

The user healthydudenextdoor starting a new topical anti-androgen hair loss treatment, Pyrilutamide, and discussing their current regimen of finasteride and minoxidil.

community Starting pyrilutamide. Currently have a 2 month supply. I will actually log my results here unlike the others

in Treatment 112 upvotes 3 years ago

Transitioning from finasteride to Pyrilutamide as a treatment for hair loss, and the potential risks associated with taking such a drug. People have discussed the need to wait at least 6 months in order to assess results, and are willing to risk their health trying this new medication.

community Anyone used the 2% pyrilutamide / KX-826 from anagenica or anywhere else?

in Product 2 upvotes 1 year ago

People are discussing hair loss treatments, including pyrilutamide, minoxidil, dutasteride, alfatradiol, and bimatoprost. Users share their experiences and side effects, noting that pyrilutamide is considered more effective and safer than RU58841.

community Pyrilutamide is available at Minoxidilmax

in Research/Science 60 upvotes 3 years ago

Minoxidilmax offering a 0.5% Pyrilutamide solution and debating the cost, effectiveness, and safety of using it alone or with other treatments such as Finasteride and Minoxidil.

community Pyrilutamide US Phase 2 Trial?

in Research/Science 27 upvotes 3 years ago

The Phase 2 trial for Pyrilutamide in the US, which started a year after the China trials, and inquiring about any available information on when it will finish. Treatments discussed include Minoxidil, Finasteride, and RU58841.

community Pyrilutamide (KX-826) personal consideration

in Research/Science 1 upvotes 11 months ago

Pyrilutamide (KX-826) is discussed as an anti-androgen treatment for hair loss, with mixed user experiences. Some users report no results, while others find it mildly effective.