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      community Has anyone else seen this encouraging verteporfin case study?

      in Progress Pictures  35 upvotes 2 years ago
      The conversation discusses the potential use of verteporfin for hair loss treatment, with one user mentioning their surgeon's interest in trying it and another noting its research status and clinical use as a YAP inhibitor. Some users debate the market size, availability of generics, and the optimism in the hair loss community regarding new treatments.

      community If PP405 works it will be fkn impossible to buy it.

      in Technology  102 upvotes 7 months ago
      PP405 is a potential hair loss treatment that may activate dormant hair follicles, but there are concerns about its effectiveness, cost, and side effects. Users discuss treatments like minoxidil, finasteride, and RU58841, expressing skepticism about PP405's long-term success and accessibility.

      community Approve PP405 quickly you coward

      in Satire  193 upvotes 11 months ago
      Pelage Pharmaceuticals is developing PP405, a topical treatment for hair growth, currently in Phase 2a trials. There is skepticism about the company's claims, and no fast-tracking approval timeline has been detailed.

      community Pelage are starting phase 3 for PP405 towards the end of 2026

      in Chat  180 upvotes 3 months ago
      PP405 is moving to late-stage trials, showing potential for hair regrowth, with 31% of male patients experiencing a 20% increase in hair density. Veradermics is developing an oral minoxidil version, and there is interest in combining treatments for better results.

      community Pp405 full presentation on new topical

      in Product  105 upvotes 2 months ago
      A new topical treatment, PP405, shows promising results for hair regrowth, potentially outperforming existing treatments like finasteride and minoxidil. However, it may still need to be combined with DHT blockers for optimal results, and its long-term effectiveness remains uncertain.

      community Month 1/4/5.5. What do you guys think about the progress?

      in Progress Pictures  6 upvotes 2 weeks ago
      The user shared progress pictures of hair growth over several months using dutasteride, finasteride, oral minoxidil, and ketoconazole. They asked for feedback on their progress, while another user suggested using a derma pen and mentioned personal experiences with hair treatments.

      community 9 months of treatment as an aggressive diffuse thinner

      in Progress Pictures  63 upvotes 3 weeks ago
      The user has been using oral minoxidil, dutasteride, RU58841, and other treatments for hair loss over nine months, seeing some improvement in hair thickness and crown volume but continued thinning at the hairline. They plan to continue treatment for another nine months despite being sensitive to DHT fluctuations and are considering increasing dosages or other options like a hair transplant.

      community 14 months - 1mg fin & 5% topical minoxidil results

      in Progress Pictures  452 upvotes 3 weeks ago
      Significant hair regrowth was achieved using 1mg finasteride and 5% topical minoxidil over 14 months, with only initial shedding and mild scalp irritation as side effects. Consistency and early treatment are recommended for optimal results.

      community What are everyone's expectations for PP405?

      in Chat  10 upvotes 4 weeks ago
      PP405 is expected to be a promising addition to hair loss treatments, potentially working well with existing treatments like finasteride and minoxidil, but not as a standalone solution. Users are hopeful for its effectiveness, especially in combination with other treatments, though expectations vary.

      community 24M planning a hair transplant, having second thoughts

      in Transplants  5 upvotes 1 month ago
      A 24-year-old is considering a hair transplant but is hesitant due to cost and finding his shaved head looks better than expected. He plans to try finasteride to improve hair density after unsuccessful attempts with minoxidil and dutasteride.

      community How is this even possible that there is no cure till now

      in Technology  155 upvotes 1 month ago
      There is no permanent cure for hair loss; treatments like finasteride, minoxidil, and hair transplants require ongoing use and are not universally effective. Genetic complexity and financial incentives for ongoing treatments hinder the development of a definitive cure.

      community Is this the 2026 Hairloss Nuclear Stack?

      in Finasteride/Dutasteride  29 upvotes 3 months ago
      A user discusses their extensive hair loss treatment regimen, which includes dutasteride, oral and topical minoxidil, RU58841, various supplements, and lifestyle changes. The conversation includes opinions on the effectiveness and necessity of such a comprehensive approach, with some users suggesting alternatives like microneedling and questioning the high dosage of dutasteride.

      community This is what finally helped me!

      in Treatment 4 months ago
      A 33-year-old woman experienced significant hair loss and found relief using Mary Ruth’s liquid morning multivitamin + hair growth and Nioxin shampoo and conditioner. She noticed reduced shedding and longer hair growth after three months of use.

      community Both oral and topical minoxidil. Any other experiences?

      in Minoxidil  1 upvotes 4 months ago
      The user is using oral and topical minoxidil, along with dutasteride, ketoconazole shampoo, fish oil, pumpkin seed oil, B complex, and other treatments, seeking better hair regrowth results. They are frustrated with the lack of substantial regrowth despite an aggressive routine and are asking for advice on using both forms of minoxidil.

      community Dutasteride appears to not be working despite 'perfect' blood results. Advice for next steps?

      in Finasteride/Dutasteride  5 upvotes 5 months ago
      The user experienced intensified hair thinning after 10 years on finasteride and saw little improvement after switching to oral minoxidil and dutasteride for 8 months. Suggestions included continuing dutasteride for another 6-8 months, considering additional treatments like topical finasteride, and evaluating nutrition and other potential causes of hair loss.

      community What do you guys think of stem cell hai restoration?

      in Chat  9 upvotes 5 months ago
      Stem cell hair restoration lacks scientific evidence and is often considered a scam. Effective hair loss treatments include hair transplants, Minoxidil, and Finasteride, but stem cell treatments are not proven.

      community Why is no one talking about coffee and TE/hairloss?

      in Treatment 5 months ago
      The conversation discusses hair loss and its potential link to caffeine consumption, with the original poster experiencing increased shedding after consuming more coffee. They mention being a non-responder to finasteride and plan to reduce coffee intake, while others suggest various factors like stress, physical exertion, and medication changes could also contribute to hair loss.
      Last Attempt at Fighting The Curse

      community Last Attempt at Fighting The Curse

      in General  210 upvotes 6 months ago
      The user is using minoxidil, finasteride, dutasteride, and clobetasol, along with needling, to combat hair loss. They are considering stopping treatment if no improvement is seen.