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      community EMA is re-examining Winlevi (clascoterone at lower concentration)

      in Treatment  8 upvotes 11 months ago
      Clascoterone in Winlevi, a topical AR antagonist, is being re-examined due to concerns about HPA axis suppression in adolescents, but it's unlikely to be banned for adult use in androgenetic alopecia (AGA). The European Medicines Agency recommended refusing Winlevi for acne vulgaris, but this may not affect Breezula's approval for AGA.

      community Pyrilutamide ,the molecule’s true nature

      in Research  302 upvotes 1 year ago
      Pyrilutamide is a selective AR antagonist with a high binding affinity, making it effective in competing with DHT for androgen receptors. The 1% concentration is more effective than the 0.5%, but the latter may suffice for mild hair loss; the drug is considered a good option for those avoiding 5AR blockers due to side effects.

      community Dutasteride with black pepper?

      in Research/Science 1 year ago
      The conversation discusses using black pepper to potentially enhance the absorption of dutasteride for hair loss treatment. It also humorously mentions other unconventional methods and ingredients like grapefruit juice and garlic.

      community Is there new research about pumpkin oil as a DHT blocker (2026)?

      in Research/Science  9 upvotes 1 month ago
      Pumpkin seed oil is considered a weak DHT blocker compared to finasteride and dutasteride, with some users reporting side effects like mood changes and reduced libido. Despite some anecdotal benefits for urinary issues, it is not effective for hair loss, and finasteride is preferred by some users for its lack of side effects.

      community Capilia Longa and scandinavian biolabs

      in Research/Science  2 upvotes 3 years ago
      Capilia Longa and Scandinavian Biolabs are discussed, with skepticism about their effectiveness and value. The conversation suggests avoiding these products due to high cost and perceived lack of results.

      community Has anyone tried Peptonix microneedling?

      in Product  4 upvotes 6 months ago
      The conversation discusses Peptonix microneedling, a copper peptide serum, as a potential hair loss treatment. Users compare it to finasteride and minoxidil, noting side effects and personal experiences with these treatments.

      community Wednesday after micro needling through Friday today.

      in Treatment  1 upvotes 1 year ago
      The user is using oral and topical minoxidil, finasteride, dutasteride, and considering adding rosemary and pumpkin saw palmetto to their regimen. They report significant hair growth, especially with dutasteride, and are considering increasing their dose and adding RU58841.

      community Which Pyrilutamide has worked the best for you ?

      in Treatment  4 upvotes 1 year ago
      The user is currently using Minoxidil with melatonin, rosemary, peppermint, azelaic acid, and RU58841 for hair loss and plans to add fluridil and Pyrilutamide. They seek advice on the best Pyrilutamide source, noting Actifolic worked briefly.

      community Fluridil solution at Actifolic

      in Treatment  4 upvotes 3 years ago
      Fluridil, also known as Topilutamide or Eucapil, is discussed as a treatment for hair loss. It is noted as an androgen receptor antagonist, not a vasodilator.

      community Pumpkin seed oil

      in General  43 upvotes 9 months ago
      The user experienced side effects from using 1% finasteride and 2% minoxidil, including dermatitis, erectile dysfunction, and heart palpitations. They switched to using 2000mg pumpkin seed oil, saw palmetto capsules, and applying pumpkin seed oil and rosemary oil twice a week, seeking feedback on results.

      community Am I missing something with pp405?

      in Research/Science  32 upvotes 1 year ago
      PP405 is discussed as a potential hair growth stimulant, possibly more effective than minoxidil, but not a cure for hair loss. There is skepticism about its ability to regrow "deadzones," and concerns about its impact on those with hair transplants.

      community Scarring Alopecia and NSAIDs?

      in Female  4 upvotes 5 years ago
      The user suspects scarring alopecia and is exploring NSAIDs and turmeric/pepper for inflammation-related hair loss, having experienced burning and thinning with finasteride and testosterone reduction. They are seeking feedback while unable to afford a dermatologist.

      community Combine minoxidil, tazarotene, lumigan

      in Treatment  3 upvotes 10 months ago
      Combining minoxidil 5%, tazarotene 0.1% cream, and lumigan for hair loss treatment is discussed. The conversation focuses on the safety and effectiveness of using these treatments together.

      community If I can’t tolerate 5ari, should I try Pyrilutamide 1%?

      in Treatment  4 upvotes 1 year ago
      The conversation is about considering pyrilutamide 1% as an alternative treatment for hair loss due to intolerance to 5-alpha reductase inhibitors. Some users suggest it might be effective, while others view it as a temporary solution.

      community Is this solution unnecessarily aggresive?

      in Product  2 upvotes 5 months ago
      The solution contains minoxidil, finasteride, azelaic acid, caffeine, retinoic acid, and procapil. Users suggest minoxidil with tretinoin and a 5-alpha reductase inhibitor, while dismissing retinoic and azelaic acids as unnecessary.

      community what do you think about Ell-Cranell + Quercetin

      in Treatment  7 upvotes 2 years ago
      The post discusses the use of El-Cranell, which contains Alfatradiol, and Quercetin as a treatment for hair loss. The user is seeking recommendations on the amount of Quercetin to add to the solution. The conclusion of the document is that Quercetin has been shown to stimulate hair growth and inhibit DHT, and combining it with zinc/copper may have a synergistic effect.

      community What happened to Breezula ????

      in Research/Science  12 upvotes 3 years ago
      The conversation discusses the effectiveness of a hair loss treatment called CB (Breezula) in comparison to Pyrilutamide, and its potential when combined with Finasteride. There is uncertainty about when or if phase 3 trials for Breezula will begin.

      community I think I am recovering from Saw Palmetto side effects!!!

       14 upvotes 9 years ago
      The user experienced negative side effects from saw palmetto, including low libido and energy, and found some improvement after using Maca and Acetyl L-Carnitine. They emphasize lifestyle changes and positivity for recovery, while expressing caution about saw palmetto's side effects.

      community Only 10 more days until cassiopea releases their 12 month results for CB-03-01 our best hope of an alternative to finasteride

      in Finasteride  154 upvotes 7 years ago
      The conversation discusses anticipation for CB-03-01, a potential new hair loss treatment that may be more effective and have a cleaner safety profile than finasteride. Users are hopeful but cautious, discussing current treatments like minoxidil, nizoral, and dermarolling, and the possibility of combining them with CB-03-01 for better results.