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GlossaryQTc interval

time for heart's electrical system to recharge, adjusted for rate

The QTc interval, or Corrected QT interval, is a measurement on an electrocardiogram (ECG) that represents the time it takes for the heart's electrical system to recharge between beats, adjusted for heart rate. It is important because a prolonged QTc interval can indicate an increased risk of life-threatening arrhythmias, such as Torsades de Pointes.

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community Will kintor show pyrilutamide phase 3 trials result this q

in Treatment 2 upvotes 2 years ago

The conversation is about the release of a new phase 3 clinical trial for a year and questioning if the results of the 6-month clinical trials will be shown this quarter. The specific treatment discussed is Pyrilutamide.

community Where are we with GT20029 ? Realistic Timeline ?

in Research/Science 7 upvotes 7 months ago

GT20029 is anticipated to start phase III trials in Q3 2026, with potential public availability around 2029-2030.

community 📈 Solving for very low dose topical finasteride titration intervals

in Research/Science 30 upvotes 1 year ago

The conversation discusses using very low dose topical finasteride to achieve specific serum DHT reduction percentages. It concludes that finasteride dosage increases linearly between 5-30% DHT reduction but requires exponential increases for reductions up to 70%.

community Q1 2024 is done. And kintor is completely silent about GT20029.

in Research/Science 31 upvotes 2 years ago

The conversation discusses the lack of updates on GT20029 for hair loss treatment, with some users noting recent reports indicating ongoing data collection. There are mentions of other treatments like Pyrilutamide and Minoxidil.

community when is kintor going to start phase 3 for gt20029?

in Research/Science 5 upvotes 1 year ago

The conversation is about the timeline for Kintor's phase 3 trials for GT20029 and the potential release of the product in three years. It also mentions treatments like Minoxidil, finasteride, and RU58841.

community Shiseido RCH-01

5 upvotes 7 years ago

Shiseido RCH-01 and Replicel's upcoming trial data release. Users discuss expected release timelines and clarify quarter dates.

community How far along is Kintor in its Phase II U.S. trials for pyrilutamide?

in Research/Science 15 upvotes 3 years ago

Kintor's Phase II U.S. trials for pyrilutamide and the process of pharmaceutical drugs coming to market, with a reply from someone who has just ordered 500mg of Pyrilutamide to start their own phase trials.

community Q1/Q2 Exciting times ahead - hope!

in Research/Science 16 upvotes 1 year ago

The conversation discusses various hair loss treatments, including Breezula, KX826, and PP405, with mixed opinions on their effectiveness compared to finasteride and minoxidil. Some users express skepticism about the new treatments, while others remain hopeful about future developments.

community How long for RU58841 to absorb?

in Treatment 4 upvotes 1 year ago

The user is concerned about safely using RU58841 around cats and wonders if applying it 2 hours before a shower is as effective as leaving it overnight. The discussion focuses on the absorption time and effectiveness of RU58841.

community bro where tf is GT20029, Q1 2024 is over already

in Research/Science 43 upvotes 2 years ago

The conversation discusses the delay in the release of GT20029 for hair loss treatment and skepticism about its effectiveness. Participants mention other treatments like verteporfin and advancements in transplant procedures as more realistic options.

community PTD-DBM Update: Q&A With Dr. Kang-Yell Choi

in Treatment 13 upvotes 6 years ago

PTD-DBM is being explored for hair regrowth by targeting CXXC5, with clinical trials expected after pre-clinical studies. Users express anticipation and skepticism about its effectiveness.

community HMI 115 Phase 1 update: Changes to clinicaltrials.gov page

in Research/Science 23 upvotes 3 years ago

A Phase 1 update for the HMI 115 clinical trial, which involves 16 participants and is expected to end in July 2023; as well as changes to the recruitment process, including treatment protocols with Minoxidil, Finasteride, and RU58841.

community Short Term Fin awaiting advances in medical technology.

in Finasteride/Dutasteride 36 upvotes 3 years ago

The user's consideration of taking finasteride as a short-term treatment, while awaiting advances in medical technology such as Pyrilutamide and GT20029; other users' experiences with Finasteride, including potential side effects.

community Where are GT20029 phase II results?

in Research/Science 3 upvotes 2 years ago

The conversation is about the anticipation of results for a hair loss treatment study, specifically for GT20029, with expectations for the results to be released in the first quarter of 2024. No specific treatments were discussed.

community Taking Potassium Chloride and Magnesium made minoxidil-induced palpitations 0

in Update 4 upvotes 3 years ago

Taking potassium chloride and magnesium stopped minoxidil-induced palpitations. The user is considering continuing minoxidil with these supplements.

community How many years can we expect PP405 to be on the market

in Product 12 upvotes 9 months ago

PP405 is expected to be on the market between 2027 and 2030, with phase 3 trials starting in 2026. There is skepticism about its fast-tracking due to its cosmetic nature, and it may appear on the gray market sooner.

community Should I switch fin dose from 2,5mg to 1,25?

in General 36 upvotes 8 months ago

The user is considering reducing their finasteride dose from 2.5mg to 1.25mg to make the supply last longer and is concerned about potential changes in results. They have been using the 2.5mg dose for four months.

community Genuine question about VDPHL01's long term safety that I haven't seen discussed here

in Research/Science 28 upvotes 2 weeks ago

Concerns about the long-term safety of VDPHL01, an extended-release minoxidil, due to potential risks similar to Cantu syndrome, were raised, highlighting the lack of monitoring for chronic connective tissue changes. The conversation suggests that while the treatment may improve hair growth, it could lead to issues not detected in short-term trials.

community The dose dependent nature of the cardiac effects RU58841

in Treatment 2 upvotes 4 months ago

Reducing the dose of RU58841 from 25mg to 7.5mg topically helped minimize heart palpitations. Users discussed the cardiac effects of RU58841 and minoxidil, noting that no treatment is completely free of side effects.

community So Pyrilutamide has been postponed by one year. How likely is that to happen to GT20029

in Treatment 27 upvotes 2 years ago

The conversation discusses the delay in the release of a new hair loss treatment, Pyrilutamide, and speculates on potential safety concerns as a reason for the delay. It also mentions GT20029 as another future treatment option, with a release at least five years away, and touches on the avoidance of research chemicals due to uncertainty about their authenticity.

community HLT Megathread on HMI-115 (key takeaways in comments)

in Research/Science 39 upvotes 3 years ago

HMI-115, a newly discovered hair loss treatment that could potentially be effective for those with diffuse thinning and telogen effluvium. It is based on prolactin receptor antagonist signaling and has already undergone Phase I trials in women, with potential commercialization by 2027.

community Kintor starts a new Phase 3 for Pyri... (1+ year)

in Research/Science 16 upvotes 2 years ago

The conversation discusses Kintor's initiation of a new Phase 3 trial to assess the long-term safety of Pyrilutamide (KX-826) for hair loss, which will last 52 weeks. Specific treatments mentioned include Pyrilutamide.

community When will GT20029 phase 3 trial begin?

in Research/Science 11 upvotes 8 months ago

The conversation discusses hair loss treatments, specifically Minoxidil, finasteride, and RU58841. It also inquires about the timeline for the GT20029 phase 3 trial by Kintor.

community Kintor KX -826 Pyrilutamide Adds 1 Year Phase 3 Trial For Safety

in Technology 54 upvotes 2 years ago

KX-826/pyrilutamide is undergoing an additional one-year safety and efficacy trial in China after a six-month study. Some participants speculate on the reasons for the extended trial and discuss the potential of other treatments.

community PP405 (Non) Update - Feb 2025

in Research/Science 34 upvotes 1 year ago

The conversation discusses the delay in the PP405 Phase 2 study results, now expected by the end of 2025, and skepticism about research practices. There is also mention of optimism for Amplifica's AMP303 and a topical treatment in early testing.

community When are the long term safety trial results for pyrilutamide due to be released?

in Research/Science 8 upvotes 1 year ago

The conversation is about the long-term safety trial results for pyrilutamide, which are expected soon. Treatments mentioned include Minoxidil, finasteride, and RU58841.

community Estimate of GT20029 on the grey market?

in Technology 9 upvotes 2 years ago

The conversation is about when GT20029, a hair loss treatment, might be available on the grey market, with users discussing the challenges of compounding it and speculating it might be available after phase 2 results, similar to pyri. Specific treatments mentioned are pyri, RU58841, and GT20029.

community How long will RU58841 remain effective after dosages are stopped?

in Product 2 upvotes 1 year ago

The conversation is about the effectiveness of RU58841 after stopping its use. The user is concerned about losing results if there's a 4-5 day gap before the next bottle arrives.

community Extreme caution: my experience using Ru58841 only once

in Treatment 10 upvotes 1 year ago

An 18-year-old experienced severe side effects, including heart palpitations and high blood pressure, after using RU58841 once, leading to a referral to cardiology for suspected left ventricular hypertrophy. The user regrets using RU58841 and seeks advice on recovery, while others suggest preexisting conditions or genetic predispositions may be factors.

community Tretinoin and Minoxidil application timeline

in Minoxidil 2 upvotes 1 year ago

The conversation is about the application timeline for tretinoin and minoxidil. It discusses whether to wait 30 minutes to an hour after applying tretinoin before using minoxidil or to apply tretinoin at night and minoxidil in the morning.