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GlossaryRitlecitinib

investigational drug targeting enzymes involved in autoimmune hair loss

Ritlecitinib is an investigational drug that targets specific enzymes known as Janus kinases (JAKs) and TEC family kinases, which are involved in the immune response. It is being studied for its potential to treat autoimmune conditions like alopecia areata, where the immune system mistakenly attacks hair follicles, leading to hair loss.

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community Anyone else taking Litfulo (ritlecitinib) to treat their alopecia?

in Treatment 6 upvotes 2 years ago

A user diagnosed with Alopecia Areata started using Litfulo (ritlecitinib), kenalog shots, and mometasone furoate 0.1%. They shaved their head and are seeking others' experiences with Litfulo.

community Article of all potential future cures

in Treatment 25 upvotes 1 year ago

Ritlecitinib and PP405 show promise for hair regrowth. Diagnosing the cause of hair loss is crucial before treatment.

community An arthritis drug that can be used for Alopecia.

in Research/Science 5 upvotes 4 years ago

An arthritis drug, baricitinib, is discussed as a potential treatment for autoimmune alopecia, not androgenetic alopecia. Ritlecitinib is also mentioned as a possible treatment for scarring alopecia.

community Update July 2025] Most Promising Hair Loss Treatments in Clinical Trials

in Research/Science 267 upvotes 11 months ago

Promising hair loss treatments in clinical trials include Pyrilutamide, GT20029, CB-03-01, and PP405, with potential market releases between 2027 and 2029. Hair cloning remains experimental and expensive, while existing treatments like finasteride, minoxidil, and microneedling continue to be used.

community Most promising cures for baldness as of May 2026

in Treatment 56 upvotes 1 month ago

PP405 is the most promising future treatment for hair loss, aiming to reactivate dormant hair follicles. Clascoterone 5% is the most promising near-term drug, while current strategies include using finasteride or dutasteride to stabilize hair loss and minoxidil to stimulate growth.

community How do we only have two treatments to combat hair loss at this point in time?

in Chat 211 upvotes 3 years ago

The post discusses frustration over the limited and not always effective treatments for hair loss, mainly Minoxidil and Finasteride. The conversation includes mentions of potential new treatments like GT20029, HMI-115, CosmeRNA, KX-826, and microneedling, but also highlights the challenges of funding and prioritizing research in this area.

community Ruxolitinib - Start of a case study

in Research/Science 10 upvotes 2 years ago

The conversation is about a user trying a new hair loss treatment, Ruxolitinib, alongside their existing regimen of finasteride, minoxidil, ketoconazole shampoo, and microneedling. They plan to apply Ruxolitinib to their temples daily for 1-2 months.

community Kintor has released an investor relations memo regarding Chinese Phase III trials for Pyrilutamide

in Update 51 upvotes 2 years ago

Kintor's Pyrilutamide (KX-826) showed hair growth in Chinese Phase III trials but did not significantly outperform placebo. The treatment was safe with no major adverse reactions reported.

community Pyrilutamide binding affinity is similar to RU

in Research/Science 16 upvotes 3 years ago

Comparing the effectiveness of RU58841, Pyrilutamide and CB-03-01 as treatments for hair loss, with people discussing different aspects such as binding affinity, time of inhibition, safety data and cost.

community Has anybody tried RU58841 and pyrilutamide together?

in Chat 10 upvotes 11 months ago

RU58841 and pyrilutamide are being discussed as potential hair loss treatments, with some users reporting side effects. There is interest in these treatments as alternatives to 5ar inhibitors and oral minoxidil due to concerns about safety and side effects.

community Kintor Phase 2 Results released KX-826 (pyrilutamide)

in Research/Science 444 upvotes 3 years ago

Kintor Pharmaceutical's Phase 2 results with the drug Pyrilutamide, a potential alternative to 5-ARI drugs like Finasteride and Dutasteride but without the side effects. It could be used in combination with other topical treatments such as Minoxidil. The safety of the drug has been demonstrated in 6 months of use, however there are still questions about long term efficacy and systemic absorption.

community Kintor announcement about pyrilutamide phase 3 results in CHINA

in Treatment 15 upvotes 2 years ago

Kintor announced Phase 3 results for pyrilutamide, a hair loss treatment, in China. The conversation is focused on this announcement and its implications for hair loss treatment.

community Anagenic is trying to compound Gt20029

in Treatment 56 upvotes 3 years ago

The conversation discusses concerns that Anagenic's version of GT20029 might not be as effective or safe as Kintor's, with comparisons to issues faced by pyrilutamide. The chemical structure of the drug has been published.

community First patient dosed with Pyrilutamide (Kintor) Phase III

in Research/Science 199 upvotes 4 years ago

First patient dosed with Pyrilutamide (Kintor) Phase III for hair loss treatment. Pyrilutamide differs from approved treatments as it competes with DHT to bind hair follicles, potentially reducing side effects.

community pyrilutamide log from someone who couldnt take fin/min/ru due to sideeffects

in Progress Pictures 105 upvotes 3 years ago

A user (seblt) who has had side effects from finasteride, minoxidil and RU58841 but is now trying pyrilutamide as a last resort, with other users providing advice and support. They have already seen some baby hairs growing after 10-14 days of treatment and will provide updates in 1-2 weeks.

community Kintor pyrilutamide presentation?

in Research/Science 12 upvotes 3 years ago

The conversation is about whether the phase 2 results for pyrilutamide, a potential hair loss treatment, were presented at a dermatology convention and inquiries about the completion of phase 3 trials. Specific treatments mentioned include pyrilutamide.

community Pyrilutamide available at Actifolic now

in Research/Science 15 upvotes 3 years ago

Pyrilutamide, a new hair loss product with the potential to be more effective than RU58841 and safer than CB, but expensive.

community Will kintor show pyrilutamide phase 3 trials result this q

in Treatment 2 upvotes 2 years ago

The conversation is about the release of a new phase 3 clinical trial for a year and questioning if the results of the 6-month clinical trials will be shown this quarter. The specific treatment discussed is Pyrilutamide.

community Kintor KX -826 Pyrilutamide Adds 1 Year Phase 3 Trial For Safety

in Technology 54 upvotes 2 years ago

KX-826/pyrilutamide is undergoing an additional one-year safety and efficacy trial in China after a six-month study. Some participants speculate on the reasons for the extended trial and discuss the potential of other treatments.

community Pyrilutamide update, comparing with ru58841

in Research/Science 25 upvotes 3 years ago

Treatments for hair loss, including Minoxidil, finasteride, and RU58841. The post discusses the potential benefits of Pyrilutamide compared to RU58841 in terms of strength and longevity.

community Pyrilutamide kintor pharmaceutical

in Chat 6 upvotes 2 years ago

The conversation is about seeking information on GT20029 from Kintor Pharmaceutical as a potential hair loss cure and inquiring about experiences with CosmeaRNA.

community Link to the conference for Kintor Pyrilutamide

in Research/Science 39 upvotes 4 years ago

User shares link to conference about Pyrilutamide. Discussion includes phase 2 results, company's plans, and upcoming phase 3 trial.

community Starting my Pyrilutamide + ru58841 journey

in Treatment 11 upvotes 3 years ago

An individual's journey to treat their severe hair loss condition using the medications Pyrilutamide and RU58841. They will provide regular updates on their progress.

community Why are there no proper phase 3 trials for RU

in Chat 4 upvotes 3 months ago

RU58841 lacks FDA approval due to financial and safety concerns, including potential cardiological side effects. The company abandoned further research, and users report adverse effects like heart palpitations and gynecomastia.

community Pyrilutamide: Increased libido. Anyone else experienced something similar with either RU or Pyri?

in Product 18 upvotes 3 years ago

An increase in libido associated with the use of Pyri, and a discussion about how it may be working comparably to other hair loss treatments such as RU58841, Finasteride and Minoxidil.

community What ever happened to pyrilutamide?

in Technology 48 upvotes 3 years ago

Pyrilutamide, a potentially effective hair loss treatment; other topical treatments like RU58841 and CB-03-01 that may have fewer side effects than Pyrilutamide; and the Phase 3 clinical trials of Pyrilutamide, which is likely to be approved by the FDA soon.

community RU58841 vs Pyrilutamide (scientist opinion)

in Research/Science 23 upvotes 3 years ago

Hair loss treatments, specifically about the effectiveness of RU58841 compared to Pyrilutamide. Molecular weights and side effects were discussed in terms of efficacy and cost-effectiveness.

community Any further update on kintor pyrilumatide treatment

in Research/Science 26 upvotes 3 years ago

Kintor Pyrilutamide treatment, a potential hair loss treatment that may become available to the public soon. People have been experimenting with using it in topical form, with mixed results and no reported side effects.

community Ru-58841 or KX-826 (Pyrilutamide)?

in Treatment 11 upvotes 3 years ago

Exploring potential treatments for hair loss, with the focus being on comparing RU58841 and Pyrilutamide. Finasteride, Dutasteride, oral Minoxidil, microneedling, topical Minoxidil, Biotin, Zinc, Vitamin D and Nizoral are also discussed as part of a treatment stack.

community Potentially Positive Pyrilutamide News Coming

in Research/Science 6 upvotes 3 months ago

Kintor Pharmaceutical's stock rise suggests potential positive news about Pyrilutamide, a topical anti-androgen. GT20029 may also compete with existing treatments like finasteride and dutasteride.