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GlossaryS100A8

protein involved in immune response and inflammation

S100A8 is a protein that plays a role in the body's immune response and inflammation. It is part of the S100 family of proteins and is often found in high levels in conditions involving chronic inflammation, such as certain types of alopecia (hair loss) and other inflammatory diseases.

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community mallia therapeutics 8T3 scd83 molecule for ffa/lpp mainly and aga

in Technology 9 upvotes 4 months ago

A user applied the 8T3 product for hair loss, targeting LPP and AGA, and plans to update on its effectiveness. The product uses a saline buffered phosphate vehicle, suitable for those intolerant to ethanolic vehicles.

community RU-58441 Janoshik test result of Made-In-China Supplier

in Product 27 upvotes 6 months ago

A user ordered RU58841 from a Chinese supplier, found it to be less than 99% pure, and plans to try a different seller next time. Concerns were raised about impurities, but the user believes they are likely inactive fillers rather than harmful substances.

community Best available SARD right now?

in Treatment 3 upvotes 1 month ago

The user is considering RU58841 and has been using dutasteride since age 17. They are seeking affordable SARD options, mentioning ASC-J9, GT20029, and AH001.

community Black market pp405? Title title

in Treatment 8 upvotes 4 months ago

PP405 is likely fake, and JXL069 is an unrefined prototype with unknown side effects. It's advised to wait for the official PP405 release.

community Pp405 any site for buying in Europe

in Product 1 month ago

PP405 is not commercially available or legitimate in Europe. Users are discussing the lack of availability of this product.

community HMI 115 hasn't done phase one yet for AGA?

in Research/Science 6 upvotes 3 years ago

User asks if HMI 115 hasn't done phase 1 for AGA in humans. Conversation includes treatments Min, Fin, and RU.

community A warning to anyone considering 3rd party sourcing PP405 or its analogs

in Treatment 31 upvotes 2 months ago

Be cautious when sourcing PP405 or its analogs from third-party suppliers due to potential safety risks and lack of regulatory approval. The conversation highlights concerns about counterfeit products and the absence of reliable testing, making it risky to use such treatments.

community Grey Market GT20029 and Frequency of Application

in Product 10 upvotes 2 years ago

The conversation is about the potential release of GT20029 on the grey market and concerns about its safety and authenticity. One user advises waiting for the official release by Kintor.

community Where are we with GT20029 ? Realistic Timeline ?

in Research/Science 9 upvotes 8 months ago

GT20029 is anticipated to start phase III trials in Q3 2026, with potential public availability around 2029-2030.

community Anyone knows if koshine kx-826 has propylene glicol?

in Product 8 months ago

Koshine KX-826 has different versions, and the green version uses a plant-based carrier that may be less irritating for those sensitive to propylene glycol. Users report irritation with some versions of KX-826.

community SUBE3 for sale in the gray market?

in Chat 4 upvotes 1 year ago

SCUBE3 is available online but poses risks like tumor promotion and high costs. Users advise against using it due to health concerns and inefficacy as a standalone treatment.

community PP405 is NOT gray market jxl069

in Technology 26 upvotes 4 months ago

PP405 is a safer alternative to JXL069 for hair loss treatment because it penetrates the skin effectively and degrades in the blood, avoiding systemic toxicity. JXL069, when forced into the body, can cause dangerous side effects like lactic acidosis due to its inability to degrade safely.

community Ethanol or PEG400 Carrier for RU58841 on Science bio

in Treatment 7 upvotes 4 years ago

The conversation discusses the best carrier for RU58841, comparing Ethanol and PEG400. The user seeks advice on which carrier is more effective.

community Any updates or news on Gt20029?

in Chat 7 upvotes 1 year ago

There are no updates on GT20029, and concerns about its safety and effectiveness remain. The phase III trial has not started, and there are no new studies or data releases.

community How many years can we expect PP405 to be on the market

in Product 12 upvotes 10 months ago

PP405 is expected to be on the market between 2027 and 2030, with phase 3 trials starting in 2026. There is skepticism about its fast-tracking due to its cosmetic nature, and it may appear on the gray market sooner.

community Chances of GT20029 hitting the black market?

in Treatment 11 upvotes 2 years ago

The conversation is about the potential availability of GT20029 on the black market and whether users would try it. Participants advise waiting for phase 3 trial results to ensure safety and efficacy.

community Best Treatment In The Pipeline?

in Chat 15 upvotes 1 year ago

New treatments for AGA are emerging, including pyrilutumide, gt0029, scube3, kx-826, and pp405. Verteporfin is mentioned as a promising option.

community Ru vendor? Looking for a cheaper source

in Product 3 upvotes 1 year ago

The conversation is about finding a cheaper source for RU58841, with a suggestion to use Chemyo. One user suggests that RU58841 may not be necessary.

community Gray market sources to get gt20029 or pp405?

in Product 2 upvotes 1 year ago

The conversation is about sourcing gray market compounds, gt20029 and pp405, for hair loss treatment. The user is interested in these compounds despite their unproven status and potential risks.

community Hope Medicine's HMI-115 could be out in 2027 per Company Founder

in Product 34 upvotes 1 year ago

Hope Medicine's HMI-115 is expected to be released in 2027, with phase 3 trials currently recruiting. Concerns include the safety of targeting prolactin and the potential cost of the treatment.

community GT20029 & KX826 Major Updates from Kintor.

in Research/Science 104 upvotes 1 year ago

KX826 shows promise as a hair loss treatment with a 10% increase in hair count, but concerns about Kintor's marketing practices and the systemic effects of treatments like GT20029 and RU58841 remain. Users express skepticism and hope, with some preferring traditional treatments like finasteride and minoxidil.

community JXL082 is not PP405 and Everychem followed the wrong lead

in Research/Science 43 upvotes 9 months ago

JXL082 is not the same as PP405, leading to a halt in sales and a plan to synthesize the real PP405. There is skepticism about the safety and effectiveness of JXL082 and PP405, with concerns about patent issues and the long-term impact on hair growth.

community Selling KY19382 powder a novel activator of Wnt/β-catenin signaling Product

in Product 3 upvotes 4 years ago

Selling KY19382 powder, a novel activator of Wnt/β-catenin signaling, and Kolliphor EL liquid for vehicle formulation. KY19382 is a growth agonist.

community RU58841 from china... Which supplier?

in Product 6 upvotes 2 years ago

The conversation is about the quality of RU58841 powder from Shaanxi Laon Biotech. The user is inquiring if anyone has experience with this product.

community GT20029 and PP405 the new fin and min that we been waiting for ?

in Chat 36 upvotes 11 months ago

PP405 and GT20029 are new hair loss treatments with different mechanisms from traditional options like Minoxidil and Finasteride. PP405 targets hair follicle stem cells to reactivate growth, while GT20029 works as an androgen receptor deleter, both requiring ongoing use for effectiveness.

community AH-001 another topical AR degrader beside GT20029, completed Phase I

in Research/Science 10 upvotes 6 months ago

AH-001 is a new topical treatment designed to degrade androgen receptors, targeting the root cause of androgenetic alopecia without the side effects of oral treatments like finasteride. It has shown a strong safety profile and good local tolerability in early trials.

community GT20029 - Stand-alone Saviour or just part of the stack?

in Research/Science 6 upvotes 3 years ago

The post discusses the potential of GT20029 in treating hair loss, questioning if it will replace finasteride or be used alongside existing treatments. A reply indicates that its role is still uncertain.

community PP405 (Non) Update - Feb 2025

in Research/Science 34 upvotes 1 year ago

The conversation discusses the delay in the PP405 Phase 2 study results, now expected by the end of 2025, and skepticism about research practices. There is also mention of optimism for Amplifica's AMP303 and a topical treatment in early testing.

community What's going on with hmi115? The Phase 2 was concluded Nov2024 but no news

in Chat 12 upvotes 6 months ago

Hmi115, a prolactin receptor blocker, showed promise for hair growth, but results from Phase 2 trials have not been published. ABS-201, an AI-based analog, is expected to begin trials in December 2025, while commercialization of treatments like PP-405 is anticipated around 2027.

community PP405 (Everychem 3HP) Users - Assemble and share your story!

in Chat 19 upvotes 4 weeks ago

Users discussed the effectiveness of Everychem's solution, similar to PP405, with some reporting improved hair thickness and new growth. Concerns were raised about safety and the legitimacy of the product, with some users advising against purchasing research chemicals.