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GlossaryTen-Eleven Translocation Methylcytosine Dioxygenase

enzyme that modifies DNA to regulate gene expression

Ten-Eleven Translocation Methylcytosine Dioxygenase, often abbreviated as TET, is an enzyme that plays a crucial role in DNA demethylation, a process that can activate or deactivate genes. TET enzymes modify methylated cytosines (a component of DNA) by converting them into hydroxymethylcytosines, which can then be further processed to remove the methyl group entirely. This activity is essential for regulating gene expression and maintaining normal cellular functions, and disruptions in TET function have been linked to various diseases, including cancer.

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community The future of hair loss drugs.

in Research/Science 32 upvotes 2 months ago

Clascoterone 5% and PP405 are being discussed as potential future treatments for hair loss, with clascoterone nearing phase three completion and PP405 possibly taking a cosmetic route to market. Current treatments like minoxidil, finasteride, and RU58841 are mentioned as effective in slowing hair loss, but a complete cure remains elusive.

community After ten weeks of microneedling

in Microneedling 154 upvotes 3 years ago

A 39 year old male who has been balding since 23 and is intolerant to finasteride, using microneedling with Derminator 2 once per week and minoxidil foam twice daily in an effort to increase thickness of vellus hairs on the crown and maintain hairline.

community Top Ten Things to Know about HT from Someone who Had it Twice

140 upvotes 6 years ago

Hair transplant tips and surgery as a last resort. Discussion includes medications, age considerations, and choosing the right surgeon.

community "After ten years of scientific research, Japanese personal care player, Shiseido has patented its RepliCel Hair-01 (RCH-01) hair regeneration technology."

35 upvotes 10 years ago

The conversation discusses Shiseido's RepliCel Hair-01 technology for hair regeneration, which aims to stop hair loss with minimal regrowth. Treatments mentioned include Minoxidil, finasteride, and RU58841.

community Coming up on ten months, I think it’s going alright!

in Progress Pictures 657 upvotes 10 months ago

The user has been using oral and topical minoxidil, finasteride, dermastamping, and multivitamins for hair loss, with plans to consider a hair transplant in the future. They are seeing gradual improvement and are content with the progress, preferring to stick with their current regimen rather than switching to other treatments like dutasteride.

community 0-5 months: almost perfect hair regrowth. But now, after ten months….

in Update 16 upvotes 11 months ago

The user experienced significant hair regrowth with topical finasteride, minoxidil, ketoconazole, and dermarolling, but later faced severe hair shedding after stopping dermarolling and reducing ketoconazole use. Suggestions included switching to oral treatments, resuming dermarolling, and considering lifestyle changes.

community How soon is hair clone? Next five years?!

in Research/Science 14 upvotes 1 year ago

Hair cloning is humorously discussed as always being 5-7 years away, with skepticism about its near-term availability. Gene editing to reactivate dormant follicles is suggested as a more likely solution within the next ten years.

community anagenic pyrilutamide powder - help me understand the pricing

in Product 2 upvotes 1 year ago

The user is confused about the pricing and concentration of pyrilutamide powder for hair loss treatment. They calculate that 500mg of pyrilutamide can make ten 1ml applications of a 5% solution, costing $119.

community Give me courage, friends! / Is finasteride response correlated with aggressiveness of hair loss?

in Finasteride/Dutasteride 6 upvotes 3 years ago

The user has been using topical finasteride for seven months and minoxidil for three years, with added tretinoin gel for ten months, and is experiencing continuous shedding without signs of regrowth. They are questioning if the amount of shedding is normal at this stage of treatment and if there's a correlation between finasteride response and the rate of hair loss.

community What fin did for me. Positive outcome (so far)

in Finasteride/Dutasteride 69 upvotes 3 years ago

A user's positive experience with finasteride for hair loss treatment, and another user's experience with minoxidil. They discuss the potential side effects of finasteride and the success they have had in regrowing baby hairs after several months of use.

community Scalp Burning After Reducing Finasteride from 1.25mg to 1mg After 10 Years

in Treatments 54 upvotes 1 month ago

The user reduced their finasteride dosage from 1.25mg to 1mg and experienced scalp burning and itching. They are concerned about potential hair loss and are seeking advice from others who have made similar dosage changes.

community 10 months on Fin plus other treatments (for more time)

in Is this regrowth? 3 upvotes 9 months ago

The user has been using minoxidil, finasteride, ketoconazole shampoo, biotin, and microneedling for hair regrowth, noticing some improvement with baby hairs and a fuller front hairline. They are considering adding rosemary oil and a dermastamp to enhance results, particularly around the thinning temple areas.

community What do you think about this study?

in Product 112 upvotes 9 months ago

The conversation discusses skepticism about new hair loss treatments, with many users expressing doubt about the effectiveness and availability of future solutions. Current treatments like minoxidil, finasteride, and hair transplants are mentioned as reliable options.

community Post FUE finasteride - moved from oral to topical

in Finasteride 90 upvotes 9 months ago

The user switched from oral to topical finasteride with minoxidil after a hair transplant and is experiencing increased hair growth in unexpected areas like eyebrows and sideburns. They are seeking feedback from others with similar experiences.

community 5% min + 1mg fin + dermaroller - 2,5 months

in Progress Pictures 48 upvotes 10 months ago

The user is using 5% minoxidil, 1mg finasteride, and a 1.5mm dermaroller 1-2 times a week for hair growth, noting improved growth speed and density. They avoid applying minoxidil immediately after dermarolling due to skin irritation.

community Shiseido's S-DSC Hair Multiplication Treatment in Japan Available to Foreign Citizens (not cheap)

in Treatment 35 upvotes 11 months ago

Shiseido's S-DSC Hair Multiplication Treatment in Japan is available to foreigners but is expensive and not very effective. Despite past disappointments, there is hope for future treatments with more options in development beyond Minoxidil and Finasteride.

community Testosterone and hair loss seeming irrelevance

in Research/Science 80 upvotes 2 years ago

The conversation is about the role of testosterone in hair loss and the effectiveness of different treatments. The conclusion is that DHT is the main culprit for hair loss, and finasteride has been proven to work long-term in maintaining and regrowing hair. Testosterone may have a minor effect, but it is not the primary cause of hair loss.

community This guy is 113 and has more hair than most people on here.

in Satire 985 upvotes 5 years ago

A 113 year old man who has more hair than most people, and the conversation is discussing potential genetic factors that may be responsible for this. Possible treatments such as dermarolling and minoxidil, finasteride, and RU58841 are mentioned.

community Scalp health/dandruff

6 upvotes 6 years ago

User is experiencing a very dry scalp with thick white flakes from using liquid minoxidil twice daily for a year. They use Nizoral every 10 days and are seeking advice for a healthier scalp, with a suggestion to use finasteride instead.

community Clascoterone powder already available?

in Product 4 upvotes 1 week ago

Clascoterone powder is now available, but it's expensive and not widely discussed due to past ineffective results at higher concentrations. Users are skeptical about its effectiveness and are seeking reliable sources.

community FDA Policy Shift Explained: What It Actually Means for PP405, VDPHL-01, Breezula and Hair Loss Drug Timelines

in Research/Science 42 upvotes 1 month ago

The FDA policy change may speed up approval for hair loss drugs like PP405, VDPHL-01, and Breezula by potentially eliminating the need for a second confirmatory Phase 3 trial. Approval timelines could be as early as 2028 for some treatments if Phase 3 results are strong.

community Is dutasteride really better than finasteride?

in Finasteride/Dutasteride 42 upvotes 2 months ago

Dutasteride is often seen as more effective than finasteride for hair regrowth, but it may cause initial shedding and takes longer to work. Combining it with treatments like minoxidil can improve results, though experiences vary.

community Single stressful event enough to trigger recurring hair loss, study suggests

in Research/Science 224 upvotes 4 months ago

Stress can trigger hair loss, with treatments like minoxidil, finasteride, and dutasteride being used to manage it. Some users report improvement with medications like Lexapro, while others emphasize the impact of stress and life events on hair health.

community What is my progress in 4 months?

in Progress Pictures 8 upvotes 6 months ago

The conversation discusses hair loss treatments, specifically the use of finasteride, minoxidil, and other methods like rosemary oil and dermastamping. The user is hesitant to start minoxidil before a hair transplant due to concerns about shedding, despite suggestions to use it for potential regrowth.

community New York Magazine article - the Great Unbalding

in Research/Science 48 upvotes 7 months ago

PP405, a potential treatment for male pattern baldness, shows promise with some participants experiencing hair regrowth in early trials. However, it is not yet considered a cure and may be used alongside existing treatments like minoxidil and finasteride.

community 2 month difference, not missing a single dose.

in Progress Pictures 491 upvotes 8 months ago

The user experienced significant hair regrowth over two months using a regimen of daily minoxidil, daily finasteride, and weekly microneedling. They reported no major side effects, except for temporary watery loads, and emphasized the importance of consistency.

community Liquid Minoxidil makes my existing hair strands very sticky and stiff, any remedy?

in Minoxidil 7 upvotes 8 months ago

Liquid minoxidil makes hair sticky and stiff; users suggest oral minoxidil or minoxidil foam as alternatives. Applying minoxidil four hours before showering can help with absorption.

community Is This A Safe Amount? 7% Minoxidil, 0.0125% Tretinoin, and 0.1% Dutasteride.

in Product 6 upvotes 8 months ago

A user discusses a dermatologist-prescribed topical solution for hair loss containing 7% Minoxidil, 0.0125% Tretinoin, and 0.1% Dutasteride, questioning its safety. Responses suggest the concentration is generally safe, though there is skepticism about daily use at high concentrations, and similar products like HairStim and Happy Head are mentioned.

community DUPA, Non Responders and Connective Tissue Disorders

in Research/Science 9 upvotes 10 months ago

A 27-year-old male with diffuse hair loss, including the donor area, did not respond to finasteride, dutasteride, or minoxidil. He suspects his hair loss may be linked to a mild connective tissue disorder, possibly affecting the structural support of hair follicles, rather than being purely hormonal.

community Some common misconceptions about why there have been no breakthroughs in treatments for so long and why a one and done cure is almost impossible.

in Treatment 53 upvotes 10 months ago

Developing new hair loss treatments is challenging due to the complexity and cost of trials, and a permanent cure is unlikely soon. Current treatments like Minoxidil and finasteride are used continuously because hair loss is progressive, and future possibilities include gene editing and hair cloning.