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GlossaryTerazosin

medication that relaxes blood vessel and prostate muscles

Terazosin is a medication primarily used to treat high blood pressure and symptoms of an enlarged prostate (benign prostatic hyperplasia). It works by relaxing the muscles in the blood vessels and the prostate, making it easier for blood to flow and for urine to pass.

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community Has anyone here been on finasteride for longer than 10 years? If so, have you had any major issues with the medicine please share your experience and how long you have taken the medicine.

in Treatment 112 upvotes 6 months ago

Long-term finasteride use typically slows hair loss, with some users experiencing side effects like sexual dysfunction and depression. Many users also use minoxidil and dutasteride for improved results, though individual responses vary.

community Can Tazarotene Upregulate Minoxidil Conversion Like Tretinoin?

in Minoxidil 2 upvotes 1 year ago

Tazarotene's potential to enhance Minoxidil conversion, similar to Tretinoin, is questioned. Users discuss the lack of information and seek further details.

community Tazarotene is extremely underrated in relation to hair regrowth

in Product 9 upvotes 3 months ago

A user discusses using tazarotene to enhance minoxidil's effectiveness for hair regrowth, believing it will make a significant difference. Others caution about potential risks of retinoids accelerating hair loss in some individuals.

community Tazarotene better than Tretinoin with minoxidil?

in Chat 9 upvotes 1 year ago

Switching from tretinoin to tazarotene with minoxidil led to new hair regrowth after years of maintenance. Tazarotene's selectivity and higher concentration might be more effective for hair growth.

community RU-58841 Experience (15mg daily dissolved in stemoxydine)

in Treatment 14 upvotes 4 years ago

User experienced reduced hair loss with 15mg RU in Serioxyl but had concerning chest pain. Others suggested consulting a doctor or lowering the dose.

community Clascoterone is the way to go if you cannot use DHT blockers

in Chat 11 upvotes 1 month ago

Clascoterone is suggested as an alternative for those who experience side effects from finasteride and dutasteride. It is not widely available yet, but some users are obtaining it from compounding pharmacies or suppliers like Echemi.

community Is tazarotene potentially better than tretinoin in combination with topical minoxidil?

in Chat 1 upvotes 8 months ago

Tazarotene may be more effective than tretinoin when combined with topical minoxidil for hair loss due to its selective binding to RAR-beta and gamma, though it can cause irritation. Tazarotene's potency can lead to indirect inflammatory reactions despite potentially causing less irritation than tretinoin.

community Group Buy for MR antagonist finerenone

in Product 11 upvotes 3 years ago

User discusses group buy for finerenone, a third-gen mineralocorticoid antagonist for hair loss treatment. Finerenone inhibits TGFb, NOX, and ROS, and improves renal and cardiac function; topical dose should be no more than 10mg per day.

community Pyrilutamide with Alfatradiol and minoxidil (23M)

in Treatment 2 upvotes 7 months ago

The user experienced side effects from a hair loss treatment and is considering using pyrilutamide, alfatradiol, and possibly minoxidil. They are unsure about starting minoxidil immediately or waiting to see the effects of the other treatments.

community Clascoterone/ Breezula will it work

in Research/Science 2 months ago

Breezula's effectiveness is uncertain, with some users skeptical about its potential and others noting its recent availability on the grey market. A user reported success with a stack of Dutasteride (oral), Minoxidil (topical), and RU58841 (topical), achieving significant hair improvement after 18 months.

community Has anyone figured out what causes the cardiovascular issues with RU?

in Chat 4 upvotes 1 year ago

RU58841 and Minoxidil can cause heart-related side effects like chest pain and heart racing. Pyrilutamide is suggested as a safer alternative, though it's new and costly.

community Pyrilutamide vs enzalutamide. Same thing?( Especially for biochemists, farmacologists)

in Research/Science 17 upvotes 3 years ago

Researching whether pyri and enza, which are stereoisomers of each other, share the same features related to CNS penetration/GABA Inhibition; safety and efficacy when used topically at 0.5-1%; and cost comparison between the two treatments.

community TRT. Pyrilutamide. Ru58841. Help

in Treatment 3 upvotes 2 years ago

A 30-year-old man experienced significant hair loss after starting testosterone replacement therapy (TRT), which did not improve with daily finasteride and minoxidil. He is considering restarting TRT and is seeking advice on using pyrilutamide or RU58841 to prevent further hair loss.

community Pyrilutamide and RU alternatives?

in Treatment 1 upvotes 1 year ago

Pyrilutamide is officially available for purchase, and users suggest Fluridil as an alternative topical anti-androgen. Some users report positive results with pyrilutamide from Koshine.

community Pyrludimide (KX-826) or Breezula (clascoterone)

in Treatment 9 upvotes 3 months ago

The conversation is about hair loss treatments, specifically Pyrludimide (KX-826) and Breezula (clascoterone), with the user unable to tolerate finasteride and dutasteride. The user plans to use these treatments alongside minoxidil, considering the efficacy and availability of each option.

community Pyrilutamide ,the molecule’s true nature

in Research 302 upvotes 1 year ago

Pyrilutamide is a selective AR antagonist with a high binding affinity, making it effective in competing with DHT for androgen receptors. The 1% concentration is more effective than the 0.5%, but the latter may suffice for mild hair loss; the drug is considered a good option for those avoiding 5AR blockers due to side effects.

community pyrilutamide solution progress log

in Product 20 upvotes 3 years ago

A 28 year old using a hair loss prevention protocol to restore thinning hair, which includes finasteride, dutasteride, minoxidil, stemoxydine, alopecin, nizoral shampoo and microneedling; the user is now adding pyrilutamide solution to the regimen with the hope of improving their results. RU58841 was also ordered but not yet used.

community Pyrilutamide cease and desist from Kintor

in Transplants 12 upvotes 3 years ago

Considering a hair transplant, using Pyrilutamide, the potential availability of CosmeRNA, and the significance of taking Minoxidil and Finasteride for long-term results.

community Pyrilutamide/KX-826 for women?

in Treatment 1 upvotes 1 year ago

Pyrilutamide/KX-826 is being considered as a potential treatment for female androgenetic alopecia (AGA), but its high cost and limited data on effectiveness are concerns. Kintor markets it for both men and women.

community Try RU or wait till another solution comes to the market

in Treatment 2 upvotes 2 years ago

The user is considering adding an anti-androgen, RU58841, to their current hair loss treatment routine due to receding hair. They are also contemplating waiting for Breezula or Pyrilutamide to become more affordable.

community Pyrilutamide starting today. 180mls.

in Finasteride/Dutasteride 15 upvotes 3 years ago

Hair loss treatments and the user's plan to start using Pyrilutamide, a combination of Minoxidil and Finasteride.

community First patient dosed with Pyrilutamide (Kintor) Phase III

in Research/Science 199 upvotes 4 years ago

First patient dosed with Pyrilutamide (Kintor) Phase III for hair loss treatment. Pyrilutamide differs from approved treatments as it competes with DHT to bind hair follicles, potentially reducing side effects.

community Koshine has anyone ever tried this?

in Treatment 1 upvotes 4 months ago

Koshine is considered less effective than finasteride, dutasteride, and RU58841 for hair loss treatment. One user reported positive results with Koshine, but others found it ineffective.

community Finally got hold of 0.1% latanoprost

in Treatment 7 upvotes 3 months ago

The conversation is about a user obtaining a compounded treatment for hair loss, including 0.1% latanoprost, 0.2% melatonin, and 1% cetirizine. The user also uses 2.5 mg dutasteride, 5 mg minoxidil, and RU58841 daily, and is at Norwood 2.

community cosmeRNA finally now it's pyrilutamide turn

in Chat 48 upvotes 3 years ago

Hair loss treatments discussed include cosmeRNA, minoxidil, finasteride, RU58841, and pyrilutamide. Users debate effectiveness, side effects, and upcoming treatments, with some expressing skepticism and others optimism.

community Pyrilutamide or RU or cb-03-01?

in Minoxidil 2 upvotes 7 months ago

The conversation discusses using Minoxidil, finasteride, RU58841, and pyrilutamide for hair loss treatment. The user is considering adding a topical treatment and has not experienced side effects from current treatments.

community Pyrilutamide - your experience?

in Product 12 upvotes 3 years ago

The conversation is about the lack of improvement in hair loss after using Pyrilutamide for 14 weeks, with the original poster unable to use Finasteride due to depression. Replies suggest that Pyrilutamide, like RU58841, may not work for everyone, and a more potent drug is being developed by Kintor.

community Combine minoxidil, tazarotene, lumigan

in Treatment 3 upvotes 11 months ago

Combining minoxidil 5%, tazarotene 0.1% cream, and lumigan for hair loss treatment is discussed. The conversation focuses on the safety and effectiveness of using these treatments together.

community Tazarotene shows strong standalone hair regrowth potential, not just a Minoxidil enhancer. Backed by VEGF, HF regeneration, and angiogenesis pathways. Here’s why.

in Research/Science 133 upvotes 11 months ago

Tazarotene shows potential as a standalone treatment for hair regrowth by stimulating new hair follicle formation and promoting angiogenesis, similar to microneedling effects. It can be used topically without minoxidil, but users should start with a low concentration to avoid irritation.

community What happened to Pyrilutamide?

in Technology 1 upvotes 1 year ago

Pyrilutamide's 0.5% solution showed minimal improvement, while the 1% solution appears more promising but costly. The user is currently using finasteride and oral minoxidil and considering adding Pyrilutamide if effective and affordable.