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GlossaryTetrahydrodeoxycorticosterone

neurosteroid modulating GABA_A receptor activity in the brain

Tetrahydrodeoxycorticosterone (THDOC) is a neurosteroid derived from the hormone deoxycorticosterone. It is known for its role in modulating the activity of the GABA_A receptor in the brain, which can influence mood, stress response, and seizure susceptibility. This compound is significant in both neuroscience and endocrinology for its potential effects on mental health and neurological conditions.

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community risks with finasteride and dutasteride

in Research/Science 141 upvotes 11 months ago

Finasteride and dutasteride have potential risks, including post-finasteride syndrome, but are commonly used for hair loss. RU58841, minoxidil, and needling are suggested as alternatives, though all treatments carry risks.

community 18M 8 months progress 40mg daily dut stack

in Progress Pictures 112 upvotes 1 year ago

An 18-year-old is using a high-dose hair loss treatment with 40mg daily dutasteride, finasteride, minoxidil, tretinoin, and topical bicalutamide. Despite health risk concerns, especially liver issues, they report hair regrowth progress and intend to continue the regimen.

community Kintor’s KX-826 Pyrilutamide!!

in Research/Science 154 upvotes 4 years ago

KX-826 hair loss treatment completed trials with mild side effects. GT20029 may be ultimate cure, destroying androgen receptors causing baldness.

community concentration of my finasteride therapy

in Finasteride/Dutasteride 4 upvotes 10 months ago

The conversation discusses a topical finasteride therapy with hydrocortisone butyrate, estrone base, and breviline. A user suggests oral finasteride as a superior option.

community What do you think about this prescription

in Treatment 2 years ago

The user visited a trichologist due to ineffective topical finasteride treatment for hair loss. The trichologist recommended a new regimen including a two-month course of locoidon (cortisone 0.1%), followed by a solution containing minoxidil, hydrocortisone butirrate, estrone, progesterone, tocopherol acetate, trichosol, and transcutol.

community Trestolone (MENT) as a nuclear treatment

in Treatment 99 upvotes 3 years ago

Experimenting with trestolone as a treatment for hair loss in an attempt to avoid DHT-related treatments such as finasteride and dutasteride, and discussing the potential effects of its receptor selectivity on the androgen receptors in the scalp.

community Reversing Hairloss with 7α-Methyl-19-Nortestosteron aka Trestolone

in Treatment 9 upvotes 1 year ago

The user experienced significant hair regrowth using Trestolone, GHK-Cu, and Minoxidil. They avoided Finasteride due to concerns about side effects and noted that their approach reduced androgenic load, contributing to hair regrowth.

community Clinical Trial: Clascoterone (Cortexolone 17A-Propionate)

in Research/Science 24 upvotes 2 years ago

A user is joining a clinical trial for Clascoterone, a drug approved for acne but being tested for hair loss. They previously tried finasteride with limited success and plan to share updates on their experience with the new treatment.

community Female AGA - Low Cortisol/Low DHEA

in Female 6 upvotes 3 years ago

Female (37) experiencing hair loss for 5 years, tried max dose of spiro and oral + topical minox without success. Discovered low cortisol and low DHEA levels, seeking functional medicine practitioner for help.

community Is hydrocortisone that bad for your scalp?

in Minoxidil 1 upvotes 1 year ago

Hydrocortisone is not recommended for long-term use on the scalp due to potential side effects like thinning and steroid-related issues. Alternatives like foam minoxidil or oral minoxidil are suggested, though foam may be less effective.

community Topical - Lantoprost .01%, MIN 10% DUT .05%, Hydrocortisone 1% Progrestron .025%

in Treatment 6 upvotes 10 months ago

A user was prescribed a topical treatment for hair loss including Latanoprost, Minoxidil, Dutasteride, Hydrocortisone, and Progesterone, after using an oral Minoxidil and Finasteride combo without significant results. Concerns were raised about the long-term use of hydrocortisone, with suggestions to consult a doctor regularly.

community Best places to get clobetasol?

in Product 1 upvotes 1 year ago

The user is considering switching to oral dutasteride, topical minoxidil, retinoic acid, and clobetasol for hair loss treatment, after limited regrowth with finasteride and other topicals. They are seeking a source for clobetasol, as they believe it may help with their condition.

community My home made topical dutasteride

in Finasteride/Dutasteride 3 upvotes 1 year ago

The conversation is about a user making a homemade topical dutasteride solution to use alongside testosterone replacement therapy (TRT) and oral dutasteride. The user aims to reduce DHT locally at the testosterone injection site and on the scalp.

community 3α-Hydroxysteroid dehydrogenase community driven study, not anytime soon guys.

in Research/Science 104 upvotes 5 years ago

High cost of studying 3α-Hydroxysteroid dehydrogenase in hair loss led to suggestions of crowdfunding for research. Users discussed using Procyanidin B2/melatonin topical treatment and tracking funds with blockchain.

community Are these a good on, what’s your opinion?

in Research/Science 2 upvotes 1 year ago

Progesterone, hydrocortisone butyrate, and estrone base are discussed as treatments for hair loss. Topical progesterone and dutasteride are suggested to potentially reverse androgenic alopecia.

community Is this hierarchy of topical anti androgens accurate?

in Ketoconazole 7 upvotes 4 years ago

User on fin, minox, and ketoconazole seeks to add another topical anti-androgen. Hierarchy of effectiveness: 1. RU55841, 2. Fluridil - Eucapil, 3. CB-03-01 - Breezula, 4. Ketoconazole; alfatradiol suggested as addition.

community How important are Retinoic and Hydrocortisone in topical serum?

in Treatment 4 upvotes 1 year ago

The conversation is about using a topical serum for hair loss with ingredients like finasteride and minoxidil, and the option to exclude retinoic acid and hydrocortisone due to concerns about long-term effects. One user prefers using only finasteride, avoiding minoxidil and retinoic acid, and plans to remove hydrocortisone in future orders.

community The ending of alopecia? Corticosterone inhibits GAS6 to govern hair follicle stem-cell quiescence

in Research/Science 64 upvotes 4 years ago

Corticosterone inhibits GAS6, affecting hair follicle stem-cell activity, with potential implications for stress-related hair loss. Ashwagandha and Vitamin K are suggested for reducing cortisol, but their effectiveness is debated.

community Intriguing Molecular Structures and Questions (DHT, Progesterone, Fin, etc)

in Research/Science 8 upvotes 2 years ago

The conversation discusses the molecular structures of compounds that reduce DHT levels, including finasteride and Ashwagandha. It explores the potential of using Ashwagandha topically as a 5a reductase inhibitor.

community Protac degradation of the androgen receptor in mice shows good efficacy and no systemic drug could be found

in Research/Science 47 upvotes 3 years ago

The efficacy of degrading the androgen receptor through dermal application in DP cells, a delivery system for topical drugs that involves dissolving microneedles, and rosemary oil as an alternative anti-androgen.

community Mechanism of action of alfatradiol (17 alpha estradiol)

in Research/Science 5 upvotes 2 years ago

The conversation discusses the mechanism of action of alfatradiol (17 alpha estradiol) in treating hair loss. It explores theories that it either inhibits 5 alpha reductase to prevent T->DHT conversion or aromatizes scalp T into 17-alpha-estradiol to save hair.

community Naturally high T (1,100+) causing diffuse thinning while on Dut

in Chat 22 upvotes 2 months ago

A 26-year-old male with high testosterone is experiencing diffuse hair thinning despite using a comprehensive treatment regimen including dutasteride, oral minoxidil, RU58841, ketoconazole shampoo, microneedling, and low-level laser therapy. Suggestions include adjusting dutasteride dosage, monitoring iron levels, and consulting a dermatologist for further evaluation.

community Comparing the effect of T suppression and DHT suppression

in Transgender 89 upvotes 1 year ago

The conversation discusses the use of 5-alpha-reductase inhibitors like finasteride and dutasteride for hair loss in transgender women, particularly in relation to testosterone suppression. The original poster has been using dutasteride and is considering stopping it due to undetectable testosterone levels.

community Clascoterone and Dutasteride for Stabilization

in Finasteride/Dutasteride 2 upvotes 2 months ago

The user is considering increasing their dutasteride dose and trying clascoterone or RU58841 for hair loss stabilization. They have used finasteride, minoxidil, and dutasteride, with some success but recent setbacks.

community OND-1 "Cyclosporine A” New hair loss treatment

in Research/Science 28 upvotes 2 months ago

Orient Bio is developing a PLGA formulated version of Cyclosporine A to stimulate hair growth without its immunosuppressant effects. Users discuss various treatments like Clascoterone, PP405, minoxidil, and tacrolimus, expressing hope for new developments and sharing personal experiences with these treatments.

community 10 Months of Nuclear Stack [Dut, Min, Keto + Estradiol & Spironolactone (MtF HRT)] -- Does it need more time or does it need a transplant?

in Progress Pictures 7 upvotes 1 year ago

The post discusses using a combination of Dutasteride, Minoxidil, Ketoconazole, Estradiol, and Spironolactone for hair regrowth. Users suggest it needs more time and possibly a transplant, with some sharing personal experiences and side effects of similar treatments.

community Does prednisolone ( oral corticoid) cause hair loss and acne?

in Question 2 upvotes 6 years ago

A user is concerned about hair loss and acne from a one-week course of 70 mg/day oral prednisolone for severe tinnitus. They are asking if these side effects are common.

community Allopregnanolone deficiency by 5-ari inhibition (fin/dut users)

in Finasteride/Dutasteride 11 upvotes 2 years ago

The conversation is about managing allopregnanolone deficiency caused by 5-alpha-reductase inhibitors like finasteride or dutasteride. Specific treatments discussed for hair loss include Minoxidil, finasteride, and RU58841.

community I'm regrowing my hair while being on the harshest steroids

10 upvotes 8 years ago

The user is regrowing hair while using steroids by following a regimen that includes Rogaine, RU58841, Dutasteride, Nizoral, PGE2, and occasionally castor oil. Despite using harsh steroids like Tren, Masteron, and Proviron, the user reports successful hair regrowth.

community Betamethasone dipropionate 0.05 (sernivo spray)

in General 76 upvotes 1 year ago

A user was prescribed betamethasone dipropionate spray for a receding hairline, which caused skin peeling and depigmentation. They stopped using it and are considering alternatives like BPC-157/TB-500 for healing.