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GlossaryDexamethasone Suppression Test

measures cortisol response to synthetic glucocorticoid dexamethasone

The Dexamethasone Suppression Test (DST) is a diagnostic procedure used to assess adrenal gland function by measuring how cortisol levels in the blood respond to an injection of dexamethasone, a synthetic glucocorticoid. It is commonly used to diagnose conditions like Cushing's syndrome, where the body produces too much cortisol.

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research Hyperandrogenic eumenorrheic NON-PCOS women versus women with PCOS after the GnRH-agonist stimulation test preceded by suppression of adrenal steroidogenesis with dexamethasone

1 citations , September 2024 in “Journal of Clinical & Translational Endocrinology”

PCOS women have more severe metabolic issues and higher androgen levels than hyperandrogenic women without PCOS.

research Differential Suppression of Testosterone and Estradiol in Hirsute Women With the Superactive Gonadotropin-Releasing Hormone Agonist Leuprolide*

49 citations , October 1988 in “The Journal of Clinical Endocrinology & Metabolism”

Leuprolide effectively reduces hair growth in hirsute women at higher doses.

research Co-secretion of testosterone and cortisol by a functional adrenocortical oncocytoma

16 citations , August 2007 in “Histopathology”

A woman's rare adrenal tumor caused high testosterone and cortisol levels, which normalized after the tumor was removed.

research Differential Diagnosis of Hyperandrogenism in Women with Polycystic Ovary Syndrome

35 citations , March 2012 in “Experimental and Clinical Endocrinology & Diabetes”

The conclusion is that accurately identifying the cause of high androgen levels in women with PCOS is crucial and requires specific tests.

research Clinical Case Seminar: Postmenopausal androgen excess-challenges in diagnostic work-up and management of ovarian thecosis

20 citations , October 2017 in “Clinical Endocrinology”

The conclusion is that removing both ovaries is the best treatment for excess male hormones in postmenopausal women, with medication as another option, and managing insulin resistance is important for diagnosis and treatment.

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