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      community Switch from fin to dut and its worse

      in Finasteride/Dutasteride  5 upvotes 11 months ago
      Switching from finasteride to dutasteride can worsen hair loss for some men due to increased testosterone levels. Topical treatments like RU58841 and Pyrilutamide are suggested to counteract these effects, but individual responses vary.

      community Post Finasteride Syndrome, A dangerous lie.

      in Chat  142 upvotes 2 years ago
      A user initially had side effects from finasteride, attributed them to anxiety and the nocebo effect, and after resuming the drug, experienced positive effects and now warns against misinformation about Post Finasteride Syndrome.
      Seeking Advice on Norwood 3 Hairline at Age 15

      community Seeking Advice on Norwood 3 Hairline at Age 15

      in Basic Questions  533 upvotes 5 months ago
      A 15-year-old is concerned about hair loss, possibly at Norwood 2 or 3, and is using shampoos and conditioners recommended by a trichologist. Suggestions include considering topical minoxidil and consulting a doctor about topical anti-DHT treatments like finasteride or RU58841, but avoiding 5-alpha-reductase inhibitors at this age.

      community [20M] Hair Regrowth with Minoxidil ONLY- Need Opinions

      in Minoxidil  244 upvotes 1 year ago
      A 20-year-old is using minoxidil for hair regrowth and considering finasteride despite concerns about side effects. Many suggest adding finasteride to maintain gains, with recommendations to start with a low dose or use a topical form to minimize side effects.

      community Proof that finasteride messes with neurosteroids

      in Research/Science  230 upvotes 1 year ago
      Finasteride can impact neurosteroids, potentially causing depression and other side effects in some users. Despite these concerns, many continue using it for hair loss, with some switching to topical applications to mitigate side effects.

      community Around 11 months of progress on hairloss medication.

      in Finasteride/Dutasteride  344 upvotes 3 years ago
      Royal_Woodpecker0007: Hahaha . No i am not naked . This conversation is about Royal_Woodpecker0007's 11-month progress on hair loss medications, including topical finasteride and minoxidil, as well as oral finasteride and keto 1% shampoo. The treatments have shown positive results, reducing his hairfall from 200 hairs per day to 40-50, and thickening his hairline. He plans to wait another year before considering a transplant.
      FCE 28260: A Forgotten 5α-Reductase Inhibitor

      community FCE 28260: A Forgotten 5α-Reductase Inhibitor

      in Research  330 upvotes 1 year ago
      FCE 28260 (PNU 156765), an under-explored 5α-reductase inhibitor, showcases promising results in research by Giudici et al., outperforming well-known treatments like Finasteride in reducing the conversion of testosterone to DHT. Its superior efficacy, demonstrated through lower IC50 values in both natural and human recombinant enzyme studies, suggests it could offer more effective management of DHT-related conditions. Additionally, its lower molecular weight hints at better potential for topical application, potentially offering advantages in treating conditions such as androgenic alopecia. Despite its potential, it has not advanced in development, possibly due to financial limitations, leaving its therapeutic prospects and side effect profile largely unexplored.

      community I am a dermatologist with a clinical interest in alopecia. AMA

      in Will treatment work for me? 3 years ago
      In this conversation, 4990 discussed various treatments for hair loss, including oral minoxidil, PRP, transplan, Jak inhibitors, Dutasteride, Finasteride, Olumiant, Ketoconazole, RU58841, microneedling, baricitinib, and CCCA. They recommended scalp biopsies in unclear cases of DUPA, twice weekly to twice daily shampooing for topical minoxidil users, and two sessions spaced one month apart with follow up at month three to determine the effectiveness of PRP treatment.

      community New and Interesting HairLoss Studies/Papers/Reviews

      in Treatment  44 upvotes 6 years ago
      Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.

      community I think this is my stop, gentlepeople. So long and thanks for all the data 👋

      in Transgender  2257 upvotes 10 months ago
      A user shared their successful experience with hair regrowth and transitioning from male to female using minoxidil, finasteride, Nutrafol, microneedling, and hormone replacement therapy (HRT). They expressed gratitude for the results and encouraged others to explore treatments that align with their personal goals.

      community All Drugs in Clinical Trials in 2023

      in Research/Science  68 upvotes 3 years ago
      12 companies having drugs or therapies in clinical trials during 2023, with various molecules and phases of trial; the probability that some may fail; and progress being made in the field.

      community How Dangerous is Oral Min Really?

      in Minoxidil  26 upvotes 1 year ago
      Oral minoxidil is generally effective for hair loss but may cause side effects like heart palpitations and facial puffiness. Users highlight the importance of monitoring blood pressure due to potential cardiovascular risks.

      community Which Minoxidil solution should i use?

      in Minoxidil  7 upvotes 2 years ago
      The user is using Minoxidil 5% with procapil spray and oral Minoxidil 2.5mg daily, and plans to add finasteride 1mg. They accidentally ordered a Minoxidil solution with finasteride 0.1% and are seeking advice on which to use.

      community Prepare to be disappointed by PP405

      in Research/Science  23 upvotes 3 months ago
      Delayed release oral minoxidil is seen as a promising advancement for hair loss treatment, offering safer, higher doses and more consistent hair follicle stimulation compared to current options. However, it is not expected to replace finasteride or dutasteride, as it does not prevent androgenetic alopecia.

      community Haircafe video on Min Sulfate, thoughts?

      in Research/Science  101 upvotes 6 months ago
      Minoxidil sulfate is considered for those unresponsive to regular minoxidil, with some trying a 10% formulation from Folligenz. Concerns exist about the product's stability and transparency, but some users report positive initial results.

      community Does Scalp tension = rise of DHT?

      in Research/Science  9 upvotes 1 year ago
      Scalp tension may contribute to hair loss by increasing DHT levels, with potential solutions like scalp massages and Botox. Concerns about finasteride's side effects were discussed, and some users shared personal experiences with alternative treatments like scalp massaging and Botox.

      community I want to attempt to use the MPC inhibitor JXL-069

      in Research/Science  14 upvotes 1 year ago
      The conversation discusses skepticism about group buys for hair loss treatments, highlighting issues with unverified chemicals and the risks involved. It suggests stabilizing with dutasteride and minoxidil, and considering a hair transplant instead of experimenting with untested products.