research Cellular and Metabolic Basis for the Ichthyotic Phenotype in NIPAL4 (Ichthyin)–Deficient Canines 21 citations , March 2018 in “American Journal Of Pathology” Mutations in NIPAL4 cause skin issues by disrupting lipid layers, but some improvement is seen with topical treatment.
research The dark and the bright sides of the transcription factor Nrf2 in skin protection and disease (Nrf2 and epidermal barrier function) August 2015 in “Free Radical Biology and Medicine” Nrf2 helps protect skin from damage but too much can cause skin problems.
research Integral hair lipid in human hair follicle 36 citations , August 2011 in “Journal of dermatological science” Human hair has a protective lipid layer that can be damaged by moisture and treatments, affecting hair growth and health.
research A keratin scaffold regulates epidermal barrier formation, mitochondrial lipid composition, and activity 98 citations , December 2015 in “The Journal of Cell Biology” Keratin is crucial for skin barrier formation and affects mitochondrial function.
research Solubility of Foreign Molecules in Stratum Corneum Brick and Mortar Structure 9 citations , January 2023 in “Langmuir” Solubility in skin changes with hydration, affecting chemical absorption.