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GlossaryCXCR4

receptor protein involved in immune cell movement and cancer

CXCR4, also known as C-X-C chemokine receptor type 4 or CD184, is a protein found on the surface of certain cells that plays a crucial role in the immune system. It acts as a receptor for a molecule called CXCL12, which helps guide the movement of cells, including immune cells, to sites where they are needed, such as areas of inflammation or injury. This receptor is also involved in the development and progression of various diseases, including cancer and HIV, making it a significant target for medical research and therapeutic interventions.

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Preconditioning With Far-Infrared Irradiation Enhances Proliferation, Cell Survival, And Migration Of Rat Bone Marrow-Derived Stem Cells Via CXCR4-ERK Pathways

research Preconditioning with far-infrared irradiation enhances proliferation, cell survival, and migration of rat bone marrow-derived stem cells via CXCR4-ERK pathways

44 citations , October 2017 in “Scientific Reports”

Far-infrared radiation improves stem cell growth and movement, helping heart therapy.

Plerixafor Engages β-Arrestin-Dependent CXCR4 Signaling to Promote Melanogenesis via β-Catenin-MITF Activation

research Plerixafor Engages β-Arrestin-Dependent CXCR4 Signaling to Promote Melanogenesis via β-Catenin-MITF Activation

July 2026 in “Current Issues in Molecular Biology”

Plerixafor may help restore skin pigmentation safely.

Plerixafor Biases CXCR4 Signaling Through β-Arrestin to Promote Melanogenesis via β-Catenin–MITF Activation

research Plerixafor Biases CXCR4 Signaling Through β-Arrestin to Promote Melanogenesis via β-Catenin–MITF Activation

March 2026 in “Preprints.org”

Plerixafor may help treat pigmentation disorders by promoting skin repigmentation.

research Regulatory T cells in skin utilize the Cxcr4-Cxcl12 axis to promote hair follicle regeneration

October 2025 in “Cell Reports”

Regulatory T cells help hair growth by using the Cxcr4-Cxcl12 pathway.

CXCL12 Inhibits Hair Growth Through CXCR4

research CXCL12 inhibits hair growth through CXCR4

April 2022 in “Biomedicine & Pharmacotherapy”

CXCL12 protein slows down hair growth through its receptor CXCR4. Blocking this can potentially increase hair growth.

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