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research FDA declines approval of testosterone drug for third time

January 2013

The FDA did not approve a testosterone drug because of safety concerns.

research The Impact of Gender Affirming Hormone Therapy on Physical Performance

July 2023 in “The Journal of Clinical Endocrinology and Metabolism”

Gender-affirming hormone therapy improves physical performance in trans men to the level of cisgender men, while in trans women, it increases fat mass and decreases muscle mass, with no advantage in physical performance after 2 years.

research Androgens’ Effects across the Lifespan in Men and Animal Models

April 2021 in “IntechOpen eBooks”

Androgens, male hormones, affect physical and mental functions, with a decrease leading to health issues like muscle loss, bone disease, and depression, and more research is needed on long-term effects and treatments.

research Late bedtime was associated with increased androgen and reduced lean mass in women with polycystic ovary syndrome: a cross-sectional study

2 citations , July 2025 in “Journal of Ovarian Research”

Going to bed late may increase hormones and decrease muscle in women with PCOS.

research Ornithine decarboxylase is upregulated by the androgen receptor in skeletal muscle and regulates myoblast proliferation

43 citations , April 2011 in “AJP Endocrinology and Metabolism”

Androgens increase muscle mass by promoting myoblast growth through ornithine decarboxylase.

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community Fin raised my estrogen but also testosterone?

in Finasteride/Dutasteride 17 upvotes 2 years ago

A user experienced initial side effects from finasteride, including erectile dysfunction and emotional changes, but later noticed increased muscle mass and assertiveness. Hormonal tests showed elevated estrogen and prolactin levels, which slightly decreased over time; the user plans lifestyle changes to see if they help.

community Train your forehead and scalp muscles

in Research/Science 23 upvotes 1 year ago

Training scalp muscles to absorb more DHT is suggested as a hair loss solution, but users debate its effectiveness compared to medications like dutasteride and finasteride. Concerns about side effects of DHT blockers, such as reduced libido, are discussed, with some advocating for natural remedies like scalp massages and healthy living.

community Massive study on finasteride side effects released

in Finasteride/Dutasteride 83 upvotes 3 years ago

The release of a study on 5a-reductase inhibitors (finasteride and dutasteride) which showed an increased risk of depression, dementia, decreased libido, and reduced semen load as potential side effects; discussion around other forms of hair loss treatments such as topical minoxidil, RU58841, or opting to accept baldness; and advice to consider professional help for deeper issues related to hair loss.

community Dutasteride Hormone Roller Coaster - Testosterone down, then up, then level, then estrogen up

in Finasteride/Dutasteride 5 upvotes 3 years ago

Dutasteride effectively stops hair loss but can cause side effects like sexual dysfunction, muscle mass changes, and testicle shrinkage. Adjusting the dosage may help manage these side effects, but long-term health effects remain a concern.

community My Testosterone is less than 1/3rd In 7 Months since I took Finasteride!

in Finasteride/Dutasteride 117 upvotes 3 years ago

A user experienced a significant drop in testosterone levels after taking finasteride, leading to side effects like low libido and muscle mass loss. Despite its effectiveness for hair, the user decided to stop finasteride due to its impact on hormones, preferring to be bald.

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