research Stress exposure modulates peptidergic innervation and degranulates mast cells in murine skin 115 citations , November 2004 in “Brain Behavior and Immunity” Stress increases nerve fibers and immune cell activity in mouse skin, possibly worsening skin conditions.
research Foot shock stress prolongs the telogen stage of the spontaneous hair cycle in a non‐depilated mouse model 31 citations , April 2007 in “Experimental Dermatology” Stress in mice delays hair growth and treatments blocking substance P can partly reverse this effect.
research Immunopathogenesis of Primary Cicatricial Alopecia December 2013 in “Research Portal (King's College London)” Hair loss in Lichen Planopilaris is caused by immune system issues damaging hair follicles and stem cells.
research Nuclear factor (erythroid-derived 2)-like-2 pathway modulates substance P–induced human mast cell activation and degranulation in the hair follicle 8 citations , May 2018 in “The Journal of Allergy and Clinical Immunology” Activating the Nrf2 pathway reduces inflammation and cell activation in human hair follicles, suggesting a potential treatment for certain hair loss conditions.
research A prostaglandind-synthase-positive mast cell gradient characterizes scalp patterning 6 citations , December 2013 in “Journal of Cutaneous Pathology” Certain immune cells are more common on the top of the head and might help predict or treat common hair loss.