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GlossaryDermal Sheath Cup Cells

specialized cells supporting hair follicle growth and regeneration

Dermal Sheath Cup Cells are specialized cells located at the base of hair follicles. They play a crucial role in hair growth and regeneration by providing structural support and signaling to the surrounding follicular cells, which helps in the cycling and maintenance of hair.

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Research

5 / 1000+ results

research Hair matrix germinative epidermal cells confer follicle-inducing capabilities on dermal sheath and high passage papilla cells

61 citations , October 1996 in “Development”

Hair growth can be stimulated by combining certain skin cells, which can rejuvenate old cells and cause them to specialize in hair follicle creation.

Morphometric Prediction of Mesenchymal Stromal Cell-Like Immunosuppressive Capacity of Human Hair Follicle Dermal Sheath Cup Cells: An Implication for Regenerative Medicine in Hair Loss Diseases

research Morphometric prediction of mesenchymal stromal cell-like immunosuppressive capacity of human hair follicle dermal sheath cup cells: an implication for regenerative medicine in hair loss diseases

November 2025 in “Stem Cell Research & Therapy”

Human hair follicle cells can help regenerate hair and reduce inflammation, aiding in hair loss treatment.

research Sprouty/FGF signaling regulates the proximal–distal feather morphology and the size of dermal papillae

50 citations , September 2012 in “Developmental Biology”

Sprouty and FGF balance is crucial for normal feather shape and size.

research The structure of the cornified claw sheath in the domesticated cat (Felis catus): implications for the claw‐shedding mechanism and the evolution of cornified digital end organs

45 citations , April 2009 in “Journal of anatomy”

Cat claws stay sharp by shedding their outer layer through microcracks formed during activities.

Comparative Spatial Transcriptomic and Single-Cell Analyses of Human Nail Units and Hair Follicles Show Transcriptional Similarities between the Onychodermis and Follicular Dermal Papilla

research Comparative Spatial Transcriptomic and Single-Cell Analyses of Human Nail Units and Hair Follicles Show Transcriptional Similarities between the Onychodermis and Follicular Dermal Papilla

10 citations , July 2022 in “The journal of investigative dermatology/Journal of investigative dermatology”

Human nails and hair follicles have similar gene activity, especially in the cells that contribute to their growth and development.

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community Scientists in Japan develop a new technique to reverse balding by transplanting a special kind of hair follicle cell into a patient's scalp

in Treatment 184 upvotes 6 years ago

A new technique developed by scientists in Japan to reverse balding using hair follicle cell transplants, and the discussion around the effectiveness of this approach compared to other treatments such as Minoxidil, finasteride, RU58841, Replicel, and Hairclone.

community Shiseido Dermal Sheath Cup (DSC) Hair Multiplication Is Finally in Japan (on July 1)

in Treatment 25 upvotes 2 years ago

Shiseido's Dermal Sheath Cup (DSC) Hair Multiplication treatment is now available in Japan. Users discuss the treatment's availability and cost.

community Shiseido filed for this patent in May 2019. Let's get some big brain discussion on this.

4 upvotes 6 years ago

The conversation discusses a patent filed by Shiseido for cloning Dermal Papilla (DP) cells to treat hair loss. The method involves using viral vectors to maintain the cells' growth-inducing properties, differing from Replicel's approach with Dermal Sheath Cup (DSC) cells.

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