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GlossaryDermal Sheath Cup Cells

specialized cells supporting hair follicle growth and regeneration

Dermal Sheath Cup Cells are specialized cells located at the base of hair follicles. They play a crucial role in hair growth and regeneration by providing structural support and signaling to the surrounding follicular cells, which helps in the cycling and maintenance of hair.

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research Hair matrix germinative epidermal cells confer follicle-inducing capabilities on dermal sheath and high passage papilla cells

61 citations , October 1996 in “Development”

Hair growth can be stimulated by combining certain skin cells, which can rejuvenate old cells and cause them to specialize in hair follicle creation.

Morphometric Prediction of Mesenchymal Stromal Cell-Like Immunosuppressive Capacity of Human Hair Follicle Dermal Sheath Cup Cells: An Implication for Regenerative Medicine in Hair Loss Diseases

research Morphometric prediction of mesenchymal stromal cell-like immunosuppressive capacity of human hair follicle dermal sheath cup cells: an implication for regenerative medicine in hair loss diseases

November 2025 in “Stem Cell Research & Therapy”

Human hair follicle cells can help regenerate hair and reduce inflammation, aiding in hair loss treatment.

research Sprouty/FGF signaling regulates the proximal–distal feather morphology and the size of dermal papillae

50 citations , September 2012 in “Developmental Biology”

Sprouty and FGF balance is crucial for normal feather shape and size.

research The structure of the cornified claw sheath in the domesticated cat (Felis catus): implications for the claw‐shedding mechanism and the evolution of cornified digital end organs

45 citations , April 2009 in “Journal of anatomy”

Cat claws stay sharp by shedding their outer layer through microcracks formed during activities.

Comparative Spatial Transcriptomic and Single-Cell Analyses of Human Nail Units and Hair Follicles Show Transcriptional Similarities between the Onychodermis and Follicular Dermal Papilla

research Comparative Spatial Transcriptomic and Single-Cell Analyses of Human Nail Units and Hair Follicles Show Transcriptional Similarities between the Onychodermis and Follicular Dermal Papilla

10 citations , July 2022 in “The journal of investigative dermatology/Journal of investigative dermatology”

Human nails and hair follicles have similar gene activity, especially in the cells that contribute to their growth and development.

research Classification of Surgical Therapies in Vitiligo

March 2018 in “John Wiley & Sons, Ltd eBooks”

Surgical therapies for vitiligo vary in effectiveness, with combination therapy and medical tattooing recommended for better results.

research Caffeine and Its Pharmacological Benefits in the Management of Androgenetic Alopecia: A Review

8 citations , January 2020 in “Skin Pharmacology and Physiology”

Caffeine improves hair growth, thickness, and reduces shedding.

research Bioengineering a 3D integumentary organ system from iPS cells using an in vivo transplantation model

77 citations , April 2016 in “Science Advances”

Researchers created a fully functional, bioengineered skin system with hair from stem cells that successfully integrated when transplanted into mice.

research Establishment of a culture model for the prolonged maintenance of chicken feather follicles structure in vitro

3 citations , October 2022 in “PloS one”

Scientists have developed a method to keep chicken feather follicles alive and structurally intact in a lab for up to a week.

research Lineage Tracing of Hair Follicle Stem Cells in Epidermal Whole Mounts

11 citations , January 2013 in “Methods in molecular biology”

The method allows for 3D tracking of hair follicle stem cells and shows they can regenerate hair for up to 180 days.

research Functional ectodermal organ regeneration as the next generation of organ replacement therapy

8 citations , March 2019 in “Open Biology”

The document concludes that regenerating functional ectodermal organs like teeth and hair is promising for future therapies.

research Molecular Signaling and Nutritional Regulation in the Context of Poultry Feather Growth and Regeneration

4 citations , January 2020 in “Frontiers in Physiology”

Good feather growth in poultry needs the right balance of proteins, amino acids, minerals, and vitamins.

research Surgical Treatment of Vitiligo

1 citations , June 2024 in “International Journal of Clinical & Experimental Dermatology”

Surgery can help treat vitiligo when other treatments don't work.

research Hot topics in pediatric dermatology

1 citations , June 2010 in “Expert Review of Dermatology”

Covers common skin issues in kids, their diagnosis, treatment, and need for specialist care.

research In vitro hair follicle growth model for drug testing

3 citations , March 2023 in “Scientific Reports”

Researchers developed a new method to test hair growth drugs and found that adult cells are best for hair growth, but the method needs improvement as it didn't create mature hair follicles.

research Epigallocatechin-3 Gallate Inhibits STAT-1/JAK2/IRF-1/HLA-DR/HLA-B and Reduces CD8 MKG2D Lymphocytes of Alopecia Areata Patients

15 citations , December 2018 in “International journal of environmental research and public health/International journal of environmental research and public health”

EGCG may help treat alopecia areata by blocking certain immune responses and reducing specific harmful immune cells.

research Hair Follicle Transit-Amplifying Cells Phagocytose Dead Cells after Radiotherapeutic and Chemotherapeutic Injuries for Timely Regeneration

3 citations , August 2023 in “Journal of Investigative Dermatology”

Actinic Keratosis: A Clinical and Epidemiological Review

research Actinic keratosis: a clinical and epidemiological revision

89 citations , June 2012 in “Anais Brasileiros de Dermatologia”

Actinic keratosis can lead to skin cancer, is more common in fair-skinned people, and can be reduced with sunscreen and treated effectively.

research Smart Microneedles for Therapy and Diagnosis

46 citations , January 2020 in “Research”

Microneedle technology has advanced for painless drug delivery and sensitive detection but faces a gap between experimental use and clinical needs.

research Therapeutic use of caffeine in dermatology: A literature review

5 citations , January 2020 in “Journal of Dermatology and Dermatologic Surgery”

Caffeine may benefit skin and hair health but more research is needed to confirm its effectiveness in dermatology.

research Hair Follicle Dermal Stem Cells Regenerate the Dermal Sheath, Repopulate the Dermal Papilla, and Modulate Hair Type

184 citations , November 2014 in “Developmental Cell”

Hair follicle dermal stem cells are key for regenerating parts of the hair follicle and determining hair type.

research Single-Cell RNA Profiling of Human Skin Reveals Age-Related Loss of Dermal Sheath Cells and Their Contribution to a Juvenile Phenotype

37 citations , January 2022 in “Frontiers in Genetics”

Aging reduces dermal sheath cells, affecting youthful skin appearance.

research Human hair follicle dermal papilla cell, dermal sheath cell and interstitial dermal fibroblast characteristics.

36 citations , September 1996 in “PubMed”

DP and DS cells are different from DF cells in structure and function.

Autologous Cell-Based Therapy for Male and Female Pattern Hair Loss Using Dermal Sheath Cup Cells: A Randomized Placebo-Controlled Double-Blinded Dose-Finding Clinical Study

research Autologous cell–based therapy for male and female pattern hair loss using dermal sheath cup cells: A randomized placebo-controlled double-blinded dose-finding clinical study

22 citations , March 2020 in “Journal of The American Academy of Dermatology”

DSC cell injections significantly improved hair density and diameter, showing potential as a hair loss treatment.

research Characterization of human dermal sheath cells reveals CD36-expressing perivascular cells associated with capillary blood vessel formation in hair follicles

16 citations , July 2019 in “Biochemical and Biophysical Research Communications”

CD36-expressing dermal sheath cells help form blood vessels in hair follicles, aiding hair growth.

research Expression of mesenchymal stem cell marker CD90 on dermal sheath cells of the anagen hair follicle in canine species

15 citations , September 2009 in “European Journal of Histochemistry”

CD90 is abundantly present on stem-like cells in dog hair follicles.

research Gene Expression Profiling of the Intact Dermal Sheath Cup of Human Hair Follicles

11 citations , January 2018 in “Acta dermato-venereologica”

Researchers found specific genes in the part of hair follicles that could help treat hair disorders.

research Human Scalp Dermal Papilla and Fibrous Sheath Cells have a different expression profile of Matrix Metalloproteinases in vitro when compared to Scalp Dermal Fibroblasts

9 citations , August 2005 in “Archives of Dermatological Research”

Scalp dermal papilla and fibrous sheath cells have different MMP expression than scalp dermal fibroblasts.

research Expression of mesenchymal stem cell marker CD90 on dermal sheath cells of the anagen hair follicle in canine species

6 citations , September 2009 in “European journal of histochemistry”

CD90 is present on specific cells in dog hair follicles.

research Progenitor-derived endothelin controls dermal sheath contraction for hair follicle regression

5 citations , January 2023 in “Nature cell biology”

A specific signal from hair cells controls the tightening of the surrounding muscle, which is necessary for hair shedding.