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GlossaryDimethyl Sulfoxide

organic solvent that penetrates biological membranes effectively

Dimethyl Sulfoxide (DMSO) is an organic compound known for its ability to penetrate biological membranes, making it useful as a solvent in pharmaceutical and medical applications. It has anti-inflammatory and analgesic properties and is sometimes used topically to relieve pain and inflammation, although its use is regulated due to potential side effects.

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research Low-Dose Dimethyl Sulfoxide (DMSO) Suppresses Androgen Receptor (AR) and Its Splice Variant AR-V7 in Castration-Resistant Prostate Cancer (CRPC) Cells

August 2025 in “Therapeutics”

Low-dose DMSO may help treat castration-resistant prostate cancer by reducing key cancer cell receptors.

research The Effect of Dimethyl Sulfoxide on Percutaneous Absorption: A Mechanistic Study, Part III

8 citations , January 1968

DMSO causes reversible swelling in hair but has a complex, less reversible effect on skin.

research Retinoic acid and dimethyl sulfoxide promote efficient delivery of transgenes to mouse skin by topically transdermal penetration

7 citations , May 2010 in “Drug Delivery”

Retinoic acid and DMSO improve gene delivery to mouse skin for potential hair and skin disease treatment.

research Effect of Incubation with Dimethyl Sulfoxide on the Mitotic Cycle of Cell Culture of Rabbit Dermal Papilla

2 citations , January 2019 in “Recent Advances in Biology and Medicine”

A 5% DMSO and 5% BSA mix best preserves rabbit dermal papilla cells during cryopreservation.

research Human epidermal transglutaminase. Preparation and properties.

138 citations , December 1976 in “Journal of Biological Chemistry”

The enzyme from human skin can cross-link proteins and needs calcium to work.

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