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research Age-related downregulation of dihydrotestosterone-inactivating enzymes in human scalp sebaceous glands

April 2026 in “Figshare”

Age-related changes in scalp glands may affect hair health, but sulforaphane might help.

research Age-related downregulation of dihydrotestosterone-inactivating enzymes in human scalp sebaceous glands

April 2026 in “Figshare”

As people age, certain enzymes in scalp glands decrease, affecting hair health.

research Age-related downregulation of dihydrotestosterone-inactivating enzymes in human scalp sebaceous glands

April 2026 in “Inflammation and Regeneration”

AKR1C enzymes in scalp glands decrease with age, possibly affecting hair loss.

Testosterone Reduces Tight Junction Complexity and Down-Regulates Expression of Claudin-4 and Occludin in the Endometrium in Ovariectomized, Sex-Steroid Replacement Rats

research Testosterone Reduces Tight Junction Complexity and Down-regulates Expression of Claudin-4 and Occludin in the Endometrium in Ovariectomized, Sex-steroid Replacement Rats

10 citations , December 2019 in “in Vivo”

Testosterone makes the connections in the uterus lining simpler and lowers certain protein levels, which might lead to infertility.

research Effects of dihydrotestosterone on rat dermal papilla cells in vitro

19 citations , April 2015 in “European Journal of Pharmacology”

Dihydrotestosterone (DHT) doesn't affect rat skin cell growth, but it does change cell cycle, protein levels, and other cell functions, potentially shortening hair growth cycle.

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Community Join

5 / 32 results

community A systematic bro-science review of DHT, 5AR, neurosteroids, sexual health and 5AR inhibitors

in Research/Science 39 upvotes 3 years ago

Hair loss treatments, specifically 5AR inhibitors, can impact neurosteroids and sexual health. The effects of topical fin/dut on tissue-specific DHT levels are unclear.

community Minoxidil is NOT an Anti-androgen. No.

in Research/Science 43 upvotes 8 months ago

Minoxidil is not an anti-androgen; it is a growth stimulator and does not lower DHT like finasteride or dutasteride. Minoxidil can cause side effects like facial swelling and anxiety due to its vasodilator properties.

community Finasteride and “anti-aging” effects

in Treatment 218 upvotes 10 months ago

Finasteride may help users look younger by suppressing DHT, affecting skin and hair. Users also emphasize skincare, sunscreen, and lifestyle for maintaining a youthful appearance.

community My understanding of how androgenetic alopecia works (plus FIN and DUT)

in Research/Science 17 upvotes 4 years ago

Androgenetic alopecia is affected by scalp DHT levels, not sensitivity, with treatments like finasteride and dutasteride aiming to optimize these levels. Personalized DHT management is crucial for effective hair growth.

community It is what it is with some people

in Satire 162 upvotes 6 months ago

Hair loss treatments like finasteride and dutasteride are discussed, with concerns about side effects such as depression and brain fog. Some users argue about the necessity and impact of DHT on libido and other bodily functions.

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