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GlossaryDystrophic Anagen Hairs

hairs in active growth phase but abnormally weak and thin

Dystrophic anagen hairs are hairs that are in the active growth phase (anagen) but are abnormally thin, weak, and often break easily due to damage or underlying health conditions. This can be caused by factors such as nutritional deficiencies, autoimmune disorders like alopecia areata, or physical trauma to the hair follicles.

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Research

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research Patients with profuse hair shedding may reveal anagen hair dystrophy: a diagnostic clue of alopecia areata incognita

31 citations , October 2010 in “Journal of the European Academy of Dermatology and Venereology”

Some people with heavy hair shedding might actually have a hidden form of alopecia, which can be identified by specific hair changes.

research Pretreatment of epidermal growth factor promotes primary hair recovery via the dystrophic anagen pathway after chemotherapy‐induced alopecia

25 citations , May 2013 in “Experimental Dermatology”

Epidermal growth factor helps hair recover after chemotherapy.

research Dystrophic-Anagen Effluvium Occurring During Pegylated Interferon-α-2a/Ribavirin Therapy

2 citations , March 2015 in “Hepatitis Monthly”

A woman's hair loss during Hepatitis C treatment with PEG-INF-a-2a and Ribavirin was reversible after stopping the medication.

research Angora Mouse Mutation: Altered Hair Cycle, Follicular Dystrophy, Phenotypic Maintenance of Skin Grafts, and Changes in Keratin Expression

69 citations , May 1997 in “Veterinary Pathology”

The angora mouse mutation causes long hair and hair defects due to a gene deletion.

research Hair loss during lithium treatment

29 citations , July 1982 in “British Journal of Dermatology”

Lithium treatment can cause increased hair shedding and hair loss in patients.

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community PP405 Won't Work Long Term: Hair Follicle Damage Due to Abuse of the ISR System

in Research/Science 66 upvotes 9 months ago

PP405 may damage hair follicles if used long-term, suggesting cycling might be necessary. Combining it with finasteride could help maintain hair growth.

community PP405 vs Hair Cloning – Which Would Be Better for NW7 to NW1?

in Research/Science 18 upvotes 10 months ago

PP405 and hair cloning are discussed as potential treatments for reversing hair loss from Norwood 7 to Norwood 1. Hair cloning is seen as a more permanent solution, while PP405's effectiveness and long-term effects remain uncertain.

community Solving Hair Loss with Research at MIT

in Research/Science 595 upvotes 1 year ago

Hair loss treatments like minoxidil, finasteride, TDM-105795, and PP405. MIT is hosting a hackathon to find innovative hair loss solutions.

community PP405 Won’t Work: Follicle Is Miniaturized, Fibrosed, And Missing Key Support Cells

in Research/Science 5 months ago

PP405 is ineffective for miniaturized, fibrosed hair follicles in androgenetic alopecia. AMP303 may activate hair follicle stem cells, but minoxidil and finasteride are still the main treatments.

community Potential ( but not yet confirmed ) pp405 leak through korean media.

in Research/Science 229 upvotes 9 months ago

A peptide-based hair loss treatment, PP405, reportedly increased hair density by 62% in 90 days, but these claims are unverified and met with skepticism. Users compared PP405 to Minoxidil and Finasteride, expressing doubts about its effectiveness without more evidence.

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learn Alopecia Areata

autoimmune disorder causing patchy hair loss

learn KY19382

compound that activates Wnt/β-catenin to promote hair regrowth and create new hair follicles

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