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GlossaryIntrinsic Aging

natural aging process driven by genetic and biological factors

Intrinsic aging, also known as chronological aging, refers to the natural and inevitable process of aging that occurs over time due to genetic and biological factors. This type of aging affects all organs, including the skin and hair, leading to changes such as thinning hair, reduced skin elasticity, and the appearance of fine lines and wrinkles. Unlike extrinsic aging, which is influenced by external factors like sun exposure and pollution, intrinsic aging is driven by the body's internal biological clock.

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Intrinsic Versus Extrinsic Aging: A Histopathological, Morphometric, and Immunohistochemical Study of Estrogen Receptor β and Androgen Receptor

research Intrinsic versus Extrinsic Aging: A Histopathological, Morphometric and Immunohistochemical Study of Estrogen Receptor β and Androgen Receptor

9 citations , January 2016 in “Skin Pharmacology and Physiology”

The study concluded that both estrogen and androgen receptors, which decrease with age, are linked to skin aging and may be hormonally regulated.

research Aging in the Male Face: Intrinsic and Extrinsic Factors

27 citations , May 2016 in “Dermatologic Surgery”

Male faces age with more wrinkles and hair loss, influenced by both body changes and environmental factors.

research Quantitative morphometric analysis of intrinsic and extrinsic skin ageing in individuals with Fitzpatrick skin types II–III

4 citations , January 2023 in “Experimental dermatology”

Skin thickness decreases and structural changes occur with both ageing and sun exposure in certain skin types.

research Skin connective tissue and ageing

77 citations , July 2013 in “Best Practice & Research in Clinical Obstetrics & Gynaecology”

Menopause reduces skin collagen and elasticity, and while estrogen therapy can help, its risks require careful consideration.

research Skin aging: are adipocytes the next target?

70 citations , July 2016 in “Aging”

Targeting dermal adipocytes may help combat skin aging.

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community Eirion Therapeutics Announces Potential Breakthrough Treatment for Hair Loss Based on First-in-Man Clinical Trial Results

in Update 415 upvotes 1 year ago

ET-02, a new hair loss treatment, shows promising results with a 6-fold increase in hair count, potentially outperforming minoxidil by activating stem cells in hair follicles. Further trials are ongoing to confirm its efficacy and safety, with potential market release in the future.

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