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research Lifestyle and Physiological Factors Associated with Facial Wrinkling in Men and Women

24 citations , April 2017 in “Journal of Investigative Dermatology”

Age, smoking, and lower BMI increase facial wrinkles; men wrinkle more than women, except in old age; pale skin and certain hormonal factors can protect against wrinkles.

research Cutaneous Manifestations of Endocrine Disease

4 citations , November 2019 in “Harper's Textbook of Pediatric Dermatology”

Endocrine diseases in children can cause various skin and hair changes.

research Adipose Mesenchymal Stem Cell‐Derived Exosomes Versus Platelet‐Rich Plasma Treatment for Photoaged Facial Skin: An Investigator‐Blinded, Split‐Face, Non‐Inferiority Trial

13 citations , May 2025 in “Journal of Cosmetic Dermatology”

Adipose mesenchymal stem cell-derived exosomes are as effective as platelet-rich plasma for improving photoaged skin and are a good option for those who prefer not to use needles.

research Main Plenary Sessions: Summaries of Papers

July 2004 in “British Journal of Dermatology”

The document concludes that accurate diagnosis and treatment are crucial in dermatology, and it presents various findings on skin conditions and treatments.

research Facial skin aging: an integrative analysis of genetics, epigenetics, and lifestyle factors

December 2025 in “GeroScience”

Genetics, epigenetics, and lifestyle all influence facial skin aging.

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community Did Dutasteride change how you look physically? your facial profile such as skin thickness, fat distribution or softness?

in Finasteride/Dutasteride 51 upvotes 11 months ago

Dutasteride and finasteride can cause changes in physical appearance, like more feminine features and increased water retention. Users report side effects such as reduced libido, weight gain, and improved skin clarity, while some notice no significant changes.

community Start taking care of your skin and hair loss TODAY! I was telling myself I didn’t care, but I think the difference in my facial expression says it all. Take action asap before more permanent damage is done. I hope I can inspire some of you, because it’s so worth it. Not for others, for yourself! <3

in Progress Pictures 583 upvotes 4 years ago

User shared progress in treating hair loss and improving skin, using treatments like finasteride, minoxidil, RU58841, tretinoin, microneedling, and skin care regimen. Others commented on the impressive results and asked about costs and side effects.

community Deep wrinkles in last year since starting oral minoxidil? Anyone else?

in Minoxidil 10 upvotes 2 years ago

A user noticed deeper facial wrinkles since starting oral minoxidil in February 2023 and is concerned about its effects on collagen production. Other factors include past accutane use, high stress, poor sleep, and COVID-19.

community Wrinkly under eyes at 24?! Possible Minoxidil side effect?

in Minoxidil 17 upvotes 5 years ago

A user noticed wrinkling under one eye, possibly due to Minoxidil use. They seek advice on preventing or fixing this issue.

community Low-dose oral minoxidil and skin aging

in Minoxidil 7 upvotes 7 years ago

The conversation discusses the use of low-dose oral minoxidil for hair loss and its potential effects on skin aging. Users shared experiences, with some noting side effects like puffy eyelids and dark circles, but no conclusive evidence of significant collagen depletion or increased wrinkles.

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