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research Review of the effects of 17α-estradiol in humans: a less feminizing estrogen with neuroprotective potential

26 citations , February 2009 in “Drug Development Research”

17α-estradiol is a safe estrogen that might protect the brain and doesn't cause feminization, needing more research for treating brain diseases.

5α-Reductase Inhibitors: Finasteride and Dutasteride in Feminizing Therapy

research 5α-reductase Inhibitors: Finasteride and Dutasteride in Feminising Therapy

6 citations , July 2026 in “Zenodo (CERN European Organization for Nuclear Research)”

Finasteride and dutasteride have limited use in feminising therapy and are not recommended for routine use.

research Effect of gender-affirming hormone therapy on hair growth: a systematic review of the literature

June 2023 in “Clinical and Experimental Dermatology”

Gender-affirming hormone therapy changes hair growth in transgender people, with feminizing therapy reducing hair and masculinizing therapy increasing it, but sometimes additional treatment is needed.

research Pharmacology of antiandrogens

97 citations , November 1986 in “Journal of Steroid Biochemistry”

Antiandrogens affect androgen-dependent body functions and are used for various medical conditions, with some risks like fetus feminization, but new forms like 17α-propylmesterolone show promise for acne without systemic effects.

research ODP021 A Feminizing Adrenocortical Carcinoma Presenting with Marie-Antoinette Syndrome

November 2022 in “Journal of the Endocrine Society”

A man's rare adrenal tumor caused feminization and white hair, was removed surgically, and improved after treatment.

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Community Join

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community Not sure what else to do, can’t use anti-androgens (Baseline Hormonal Bloodwork included) need advice badly

in Update 4 upvotes 5 years ago

User experienced feminizing side effects from finasteride and tried RU, alfatradiol, and finasteride without success. They are now considering treatments like Stemoxydine, Zix, Minoxidil, Dermarolling, Eucapil, and a hair transplant.

community My friend is so terrified of balding, he started microdosing estrogen…

in Treatment 1522 upvotes 7 months ago

A person is microdosing estrogen for hair loss after finasteride and dutasteride failed, risking feminizing effects. Alternatives like minoxidil, RU58841, or hair transplants are suggested.

community why isn’t RU / pyri blamed for feminization, whereas spiro is?

in Treatment 3 years ago

User asks if spironolactone can stack with finasteride and pyrilutamide for hair loss treatment. They question why spironolactone is associated with feminizing effects, while RU/pyri/fluridil, which work similarly, are not.

community (MTF 35) Results of 18 Months of HRT

in Transgender 783 upvotes 6 months ago

A transgender woman experienced significant hair regrowth after 18 months of hormone replacement therapy (HRT) with estrogen and bicalutamide. The discussion notes HRT's effectiveness for hair regrowth but warns against its use for cisgender men due to feminizing effects.

community 2 months of difference with estradiol and spiro (4 months total w/ estradiol & spiro; 4 years of minoxidil and finasteride) (you should not take estradiol or spiro if you look manly and want to continue looking manly)

in Transgender 120 upvotes 1 year ago

Hair regrowth using estradiol, spironolactone, minoxidil, and finasteride, showing significant improvement over four years. HRT is not advised for cis men solely for hair loss due to feminizing effects.

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