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Feminizing Hormone Therapy

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research Review of the Effects of 17α-Estradiol in Humans: A Less Feminizing Estrogen with Neuroprotective Potential

26 citations , February 2009 in “Drug Development Research”

17α-estradiol is a safe estrogen that might protect the brain and doesn't cause feminization, needing more research for treating brain diseases.

research Neural Substrates of the Emotional Negativity Bias as Revealed by Hemodynamic Data

July 2008 in “International journal of psychophysiology”

Cyproterone acetate is a safe treatment that causes mild feminizing effects in adolescent trans-girls.

research Anterior Extra-Dural Clinoidectomy in the Approach to Supratentorial Skull Base Meningiomas: A Series of 142 Cases

November 2007 in “Neuro-chirurgie/Neurochirurgie”

Cyproterone acetate is a safe treatment that causes mild feminizing effects and is more effective with added estrogens.

research Advances in Knowledge of Androgens: How Intentional and Accidental Neurosteroid Changes Inform Us of Their Action and Role

December 2020 in “Current Sexual Health Reports”

Finasteride can have lasting negative effects on brain function and behavior by disrupting neurosteroid production.

research Consecutive Cyproterone Acetate and Estradiol Treatment in Late-Pubertal Transgender Female Adolescents

36 citations , May 2017 in “The journal of sexual medicine”

Cyproterone acetate treatment is safe and causes mild feminization, which increases with added estrogen.

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community My friend is so terrified of balding, he started microdosing estrogen…

in Treatment 1522 upvotes 1 month ago

A person is microdosing estrogen for hair loss after finasteride and dutasteride failed, risking feminizing effects. Alternatives like minoxidil, RU58841, or hair transplants are suggested.

community (MTF 35) Results of 18 Months of HRT

in Transgender 763 upvotes 2 weeks ago

A transgender woman experienced significant hair regrowth after 18 months of hormone replacement therapy (HRT) with estrogen and bicalutamide. The discussion notes HRT's effectiveness for hair regrowth but warns against its use for cisgender men due to feminizing effects.

community 2 months of difference with estradiol and spiro (4 months total w/ estradiol & spiro; 4 years of minoxidil and finasteride) (you should not take estradiol or spiro if you look manly and want to continue looking manly)

in Transgender 121 upvotes 1 year ago

Hair regrowth using estradiol, spironolactone, minoxidil, and finasteride, showing significant improvement over four years. HRT is not advised for cis men solely for hair loss due to feminizing effects.

community why isn’t RU / pyri blamed for feminization, whereas spiro is?

in Treatment 2 years ago

User asks if spironolactone can stack with finasteride and pyrilutamide for hair loss treatment. They question why spironolactone is associated with feminizing effects, while RU/pyri/fluridil, which work similarly, are not.

community Hair loss steps, guide to beginners or anyone experiencing hair loss

in Treatment 1 upvotes 1 year ago

The conversation discusses a hair loss treatment regimen involving finasteride, dutasteride, spironolactone, bicalutamide, oral estradiol, microneedling, and minoxidil. The regimen aims to reduce androgenic alopecia by blocking DHT and androgens, with a caution about potential feminizing effects.

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