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Dynamic Changes in Fibroblast Subpopulations Drive Development of Radiation-Induced Skin Fibrosis Through the Fra/c-Jun Pathway

research 1493 Dynamic changes in fibroblast subpopulations drives development of radiation-induced skin fibrosis through the fra/c-jun pathway

April 2023 in “Journal of Investigative Dermatology”

Radiation treatment causes skin fibrosis by increasing certain fibroblast subpopulations, but using a c-Jun inhibitor or fat grafting can reduce this effect.

research Imbalanced redox dynamics induce fibroblast senescence leading to impaired stem cell pools and skin aging

7 citations , March 2025 in “Free Radical Biology and Medicine”

Imbalanced redox dynamics cause skin aging by damaging fibroblasts and stem cells.

research Formation of actin mesh structures and alpha-smooth muscle actin dynamics in fibroblasts contribute to dermal regeneration in mouse fetus

1 citations , September 2025 in “PLoS ONE”

Actin and alpha-smooth muscle actin help skin heal in mouse fetuses.

research Integrated Single-Cell Analysis Reveals Spatially and Temporally Dynamic Heterogeneity in Fibroblast States during Wound Healing

21 citations , July 2024 in “Journal of Investigative Dermatology”

Plasticity and Cytokinetic Dynamics of the Hair Follicle Mesenchyme During the Hair Growth Cycle: Implications for Growth Control and Hair Follicle Transformations

research Plasticity and Cytokinetic Dynamics of the Hair Follicle Mesenchyme During the Hair Growth Cycle: Implications for Growth Control and Hair Follicle Transformations

54 citations , June 2003 in “The journal of investigative dermatology. Symposium proceedings/The Journal of investigative dermatology symposium proceedings”

Disruptions in hair follicle fibroblast dynamics can cause hair growth problems.

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