Imbalanced Redox Dynamics Induce Fibroblast Senescence Leading to Impaired Stem Cell Pools and Skin Aging
March 2025
in “
Free Radical Biology and Medicine
”
redox dynamics fibroblast senescence stem cell pools skin aging oxidative stress mitochondrial dysfunction reactive oxygen species ROS redox-sensitive transcription factor JunB p16INK4A IGF-1 senescence-associated secretory phenotype SASP collagen degradation skin tensile strength redox-imbalanced senescent fibroblasts collagen skin health
TLDR Imbalanced redox dynamics cause skin aging by damaging fibroblasts and stem cells.
The study investigates how imbalanced redox dynamics lead to fibroblast senescence, impairing stem cell pools and contributing to skin aging. Key factors include oxidative stress, mitochondrial dysfunction, and increased reactive oxygen species (ROS), which activate the redox-sensitive transcription factor JunB, increasing p16INK4A expression and decreasing IGF-1 release. This results in the senescence-associated secretory phenotype (SASP), collagen degradation, and reduced skin tensile strength. The findings highlight the potential of targeting redox-imbalanced senescent fibroblasts to address skin aging and related diseases, emphasizing the importance of maintaining redox balance for skin health and delaying aging.
