March 2024 in “Jagiellonian University Repository (Jagiellonian University)” Genetic and lifestyle factors influence skin and hair aging, and prediction models can help assess aging and cosmetic treatments.
December 2025 in “GeroScience” This study investigates the impact of genetics, epigenetics, and lifestyle on facial skin aging, analyzing over 700 Polish individuals. It identifies novel genes, such as EDAR and NRG1, linked to facial wrinkles and highlights the role of environmental stressors. Epigenetic aging correlates with facial wrinkle area and perceived age, with GrimAge and FitAge clocks showing strong associations. Genome-wide SNP analysis reveals associations with wrinkle area and perceived age, suggesting stress response and adiposity involvement. The study demonstrates that combining methylation and SNP data can predict variations in skin phenotypes, explaining 59.0% of wrinkle area and 26.2% of perceived age, offering valuable insights for dermatology and anti-aging strategies.