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GlossaryFollicular Papules

small, raised bumps around hair follicles

Follicular papules are small, raised bumps on the skin that form around hair follicles. They can result from various conditions, such as keratosis pilaris or folliculitis, and are often caused by inflammation or blockage of the hair follicles. These papules are typically harmless but can sometimes be itchy or cosmetically concerning.

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Research

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research Dihydrotestosterone-Inducible Dickkopf 1 from Balding Dermal Papilla Cells Causes Apoptosis in Follicular Keratinocytes

171 citations , July 2007 in “Journal of Investigative Dermatology”

A substance called DKK-1 increases in balding areas and causes hair cells to die when exposed to DHT.

research Simple and rapid method to isolate and culture follicular papillae from human scalp hair follicles

78 citations , August 2002 in “Experimental Dermatology”

Researchers developed a quick and easy way to get and grow cells from the base of human hair follicles.

Follicular Dermal Papilla Structures by Organization of Epithelial and Mesenchymal Cells in Interfacial Polyelectrolyte Complex Fibers

research Follicular dermal papilla structures by organization of epithelial and mesenchymal cells in interfacial polyelectrolyte complex fibers

40 citations , June 2013 in “Biomaterials”

Scientists created 3D hair-like structures that could help study hair growth and test treatments.

research Message of nexin 1, a serine protease inhibitor, is accumulated in the follicular papilla during anagen of the hair cycle

37 citations , December 1995 in “Journal of Cell Science”

Nexin 1 may help control hair growth.

research Trypsin-induced follicular papilla apoptosis results in delayed hair growth and pigmentation

29 citations , April 1997 in “Developmental Dynamics”

Trypsin slows hair growth and affects color by causing cell death in hair follicles.

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community Targeted Follicular Finasteride Delivery: A Low-Systemic Strategy

in Research/Science 15 upvotes 4 months ago

A peptide-based delivery system for finasteride shows promise in reducing systemic side effects while maintaining hair growth effectiveness. Combining this with other treatments like minoxidil and RU58841 could enhance results with lower systemic absorption.

community Looks like a real cure to the root of baldness (DHT-induced senescence) was proven earlier this year

in Research/Science 734 upvotes 3 years ago

A study that outlines the full model for androgenic alopecia (AGA) which links DHT to cellular senescence in dermal papilla cells, and suggests black chokeberry as a source of cyanidin 3-O-arabinoside polyphenol with potential anti-oxidant properties that could reverse this process. The post encourages reaching out to experts in anti-aging and longevity to research treatments involving the polyphenol.

community New and Interesting HairLoss Studies/Papers/Reviews

in Treatment 42 upvotes 6 years ago

Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.

community Possible topical option for preventing BDNF-related hair loss

in Research/Science 8 upvotes 2 years ago

The conversation discusses hair loss linked to BDNF-increasing nootropics like Semax and Lions Mane. Suggested topical treatments include capsaicin, beta-glucan, and ginseng to counteract TGF-B activation.

community Most promising cures for baldness as of May 2026

in Treatment 67 upvotes 2 months ago

PP405 is the most promising future treatment for hair loss, aiming to reactivate dormant hair follicles. Clascoterone 5% is the most promising near-term drug, while current strategies include using finasteride or dutasteride to stabilize hair loss and minoxidil to stimulate growth.

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