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research The Rho GTPase exchange factor Vav2 promotes extensive age-dependent rewiring of the hair follicle stem cell transcriptome

September 2023 in “Frontiers in cell and developmental biology”

Vav2 changes how hair follicle stem cells' genes work as they age, which might improve regeneration but also raise cancer risk.

research Skin aging: mechanisms, evaluation, and rejuvenation

May 2026 in “The EMBO Journal”

Skin aging can be slowed by targeting cells, hormones, and the microbiome.

Transcriptome Analyses of Reprogrammed Feather/Scale Chimeric Explants Revealed Co-Expressed Epithelial Gene Networks During Organ Specification

research Transcriptome analyses of reprogrammed feather / scale chimeric explants revealed co-expressed epithelial gene networks during organ specification

7 citations , October 2018 in “BMC genomics”

Key genes can rewire networks, changing skin appendage types.

research The Rho guanosine nucleotide exchange factors Vav2 and Vav3 modulate epidermal stem cell function

3 citations , May 2022 in “Oncogene”

Vav2 and Vav3 proteins help control skin stem cell numbers and activity in both healthy and cancerous cells.

research Integrated analysis of lncRNAs and mRNAs by RNA-Seq in secondary hair follicle development and cycling (anagen, catagen and telogen) of Jiangnan cashmere goat (Capra hircus)

24 citations , May 2022 in “BMC Veterinary Research”

lncRNAs play a key role in hair follicle development, affecting cashmere quality and yield.

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community Hair Loss Breakthrough: Keratin Microsphere Gel Initiates Hair Regrowth in Days by Directly Targeting Follicles and Boosting Gene Expression - Gilmore Health News

in Treatment 464 upvotes 2 years ago

A new hair loss treatment involving Keratin Microsphere Gel is discussed, with skepticism and jokes about its effectiveness and comparisons to other treatments. Users are doubtful and make light of the situation, referencing past disappointments and the study's focus on mice.

community Why dont we research more on body hair

in Chat 32 upvotes 4 months ago

Body hair is more resilient than scalp hair due to different gene expressions and DHT sensitivity. Treatments like minoxidil and finasteride are used for hair loss, but they have varying effects on body and scalp hair.

community I believe CRISPR-on & CRISPR-off is an ultimate CURE for baldness, unlike Hair Cloning or hair loss treatments.

in Research/Science 24 upvotes 5 years ago

The conversation discusses CRISPR-on & CRISPR-off as a potential cure for baldness, contrasting it with hair cloning and other treatments like Minoxidil, finasteride, and RU58841. It also mentions the potential of mRNA for gene expression control and the prioritization of gene editing for severe genetic conditions.

community TWIST-1 and the cure: Is it really that easy?

in Research/Science 283 upvotes 4 years ago

TWIST-1 gene's role in hair loss and potential as a treatment target. Inhibiting TWIST-1 may prolong hair growth and reduce hair follicle sensitivity to DHT.

community Has anyone used Magnesium L-Threonate ?

70 upvotes 7 years ago

Magnesium L-Threonate may help treat balding by reducing DKK-1 expression without affecting DHT. Users discuss its potential effectiveness and application methods, with some considering trying it topically.

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