Skin Aging: Mechanisms, Evaluation, And Rejuvenation

May 2026 in “ The EMBO Journal ”

Runhan Li, Jingyun Zhang, Kehang Mao, Dawei Meng, Jing-Dong J Han

cellular senescence microbiome hormonal signaling gene expression rewiring metabolic modulation microenvironmental modulation hormone regulation regenerative therapies

TLDR Skin aging can be slowed by targeting cells, hormones, and the microbiome.

The document explores the mechanisms of skin aging, emphasizing the roles of cellular senescence, disrupted communication between skin layers, and dysregulation of the microbiome and hormonal signaling in compromising skin structure and function. It discusses advances in evaluating skin aging through molecular and phenotypic indices, which help assess biological age and the effectiveness of interventions. The paper also highlights rejuvenation strategies, including gene expression rewiring, metabolic and microenvironmental modulation, microbiome adjustments, and hormone regulation, providing a framework for precision interventions and regenerative therapies.

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