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GlossaryBulge Region

specific area in hair follicle housing stem cells

The bulge region is a specific area located in the outer root sheath of a hair follicle. It contains a reservoir of stem cells that are crucial for hair growth and regeneration. These stem cells can also contribute to the repair of the skin and other tissues, making the bulge region essential for both hair health and overall skin maintenance.

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Research

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The Contributory Roles of Th17 Lymphocyte and Cytotoxic T Lymphocyte at the Hair Bulge Region and Hair Bulb Area in Chronic Alopecia Areata Patients

research The Contributory Roles of Th17 Lymphocyte and Cytotoxic T Lymphocyte at the Hair Bulge Region as Well as the Hair Bulb Area in the Chronic Alopecia Areata Patients

18 citations , January 2017 in “Annals of dermatology/Annals of Dermatology”

Certain immune cells contribute to severe hair loss in chronic alopecia areata, with Th17 cells possibly having a bigger impact than cytotoxic T cells.

research Autofluorescence in the Stem Cell Region of the Hair Follicle Bulge

17 citations , March 2005 in “Journal of Investigative Dermatology”

Autofluorescence in hair follicle stem cells can interfere with studies but may help isolate these cells.

research 083 More Expression of IL-17 than IFN-γ from CD49a-negative Tissue-Resident Memory T (Trm) cells at the Hair Bulge and Hair Bulb Region in the Scalp of Chronic Alopecia Areata Patients according to the Foxp3+mTregs depletion

September 2019 in “Journal of Investigative Dermatology”

IL-17 and certain immune cells are linked to more severe alopecia areata.

research Basal cell carcinoma possibly originates from the outer root sheath and/or the bulge region of the vellus hair follicle

107 citations , May 1999 in “Archives of Dermatological Research”

Basal cell carcinoma may start from parts of tiny hair follicles.

Involvement of the Bulge Region with Decreased Expression of Hair Follicle Stem Cell Markers in Senile Female Cases of Alopecia Areata

research Involvement of the bulge region with decreased expression of hair follicle stem cell markers in senile female cases of alopecia areata

20 citations , December 2010 in “JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology”

Decreased CD200 in hair follicles may cause immune issues in some alopecia areata cases.

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Community Join

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community Hair theory Scar tissue and Verteporfin

in Chat 25 upvotes 2 years ago

A user suggests that deeper microneedling with Verteporfin injections might help regrow hair in areas with scar tissue, alongside a DHT blocker. Another user explains that hair loss might be due to reduced Wnt/β-Catenin signaling and suggests that treatments like Minoxidil, Finasteride, and microneedling could potentially reverse it.

community DHT Isn’t the Only Factor in Hair Loss and That Might Be the Key to a Real Cure

in Research/Science 370 upvotes 4 months ago

Hair loss involves more than just DHT, with genetic factors like TRPS affecting hair follicles. Treatments such as Amplifica's AMP-601 and AMP-303 target stem cells for potential hair growth solutions.

community UVA researchers discovered stem cells that plays a crucial role in hair growth - We are closer than ever to the cure!

in Research/Science 282 upvotes 1 year ago

Researchers at the University of Virginia discovered a new group of stem cells in hair follicles that could potentially restore hair growth. The findings suggest that activating these stem cells might offer a new way to combat hair loss, though practical treatments are still years away.

community Neck tension, and hair loss, I am 100 percent sure that there is a connection

in Treatment 19 upvotes 2 years ago

The user believes neck tension and poor posture contribute to hair loss, noticing improvements with yoga and muscle relaxation. Replies suggest androgenic alopecia as the cause and recommend exercises.

community It's always the Mice that gets to grow back hair.

in Research/Science 431 upvotes 8 months ago

Sodium dodecyl sulfate, oleic acid, and palmitoleic acid may promote hair growth, but their safety and effectiveness for humans are uncertain. Users consider trying these treatments cautiously, exploring alternatives like ostrich oil and microneedling.

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learn Beta Polypeptide

learn Thymosin Beta 4

learn Stem Cell Factor

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