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GlossaryHair Follicle Apoptosis

programmed cell death within hair follicles

Hair follicle apoptosis refers to the programmed cell death of cells within the hair follicle. This process is a natural part of the hair growth cycle, particularly during the transition from the growth phase (anagen) to the regression phase (catagen), and it helps regulate hair growth and shedding.

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Research

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research Hair Follicle Apoptosis and Bcl-2

54 citations , December 1999 in “Journal of Investigative Dermatology Symposium Proceedings”

research The anti‐apoptotic Bcl‐2 protein regulates hair follicle stem cell function

10 citations , August 2021 in “EMBO Reports”

The Bcl-2 protein is important for keeping hair follicle stem cells working and preventing hair loss.

research Pathobiology of the hairless phenotype: Dysregulation of hair follicle apoptosis and topobiology during the initiation of follicle cycling

9 citations , March 1998 in “Journal of Dermatological Science”

Improper regulation of hair follicle processes causes hairlessness.

research Yangxuebushen Decoction prevents cyclophosphamide-induced hair loss by inhibiting hair follicle apoptosis

January 2026 in “Cutaneous and Ocular Toxicology”

Yangxuebushen Decoction helps prevent hair loss from chemotherapy.

research Enhancement of In Vitro Hair Shaft Elongation in Follicles Stored in Buffers That Prevent Follicle Cell Apoptosis

10 citations , January 2004 in “Dermatologic Surgery”

Storing hair follicles in special buffers with added protective substances can increase hair growth and reduce cell death.

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Community Join

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community [Nov 2019] The peptide AC 2 isolated from Bacillus-treated Trapa japonica fruit extract rescues DHT (dihydrotestosterone)-treated human dermal papilla cells and mediates mTORC1 signaling for autophagy and apoptosis suppression

22 upvotes 6 years ago

A peptide from Japanese water chestnut fruit may help with hair loss by suppressing DHT's effect on hair follicle cell death, potentially serving as a finasteride alternative. The treatment's effectiveness and safety in humans remain uncertain.

community How all hormones affect our hair follicles. Not just DHT. Take a look at this paper. Prolactin, melatonin, cortisol, progesterone, testosterone and more

in Research/Science 126 upvotes 3 years ago

The conversation discusses various factors affecting hair loss, not just DHT, and mentions treatments like Minoxidil, finasteride, and melatonin. Some users report personal experiences with these treatments and hormone tests, while others speculate on the role of hormones like prolactin and cortisol in hair loss.

community Weed/THC effects on hair growth/hair loss, and vitality of organ-culture human follicle studies (research review)

in Research/Science 5 upvotes 1 year ago

Cannabis and THC may have mixed effects on hair, with some studies suggesting potential negative impacts on hair growth in isolated hair follicles, but these results are hard to apply to living humans. Treatments like minoxidil and finasteride are commonly used for hair loss, and the effects of cannabis might be neutral or vary based on individual factors.

community Dht kills hair, but no one says why?

in Finasteride/Dutasteride 40 upvotes 11 months ago

DHT affects hair follicles, contributing to hair loss, but the exact mechanism is unclear. Treatments like finasteride and minoxidil are used to manage hair loss, though they may have side effects and varying effectiveness.

community The end of balding: We may have just found the secret to hair regrowth

in Technology 680 upvotes 1 year ago

MCL-1 is important for hair follicle stem cell survival, but its impact on human hair regrowth is unclear. Minoxidil and finasteride are the main treatments, with doubts about new discoveries leading to effective human solutions soon.

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Learn

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learn Dexpanthenol

precursor of vitamin B5 with hair stimulating effects

learn GHK-Cu

a copper peptide showing promise in both regrowth and reversing gray hair

learn Procyanidin

bioflavonoid found in plants with antioxidant and hair stimulating properties

learn Melatonin

hormone commonly taken for sleep aid has some topical benefits for hair

learn Overview

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Clinics

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Experts

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