Corticosterone inhibits GAS6, affecting hairfolliclestem-cellactivity, with potential implications for stress-related hair loss. Ashwagandha and Vitamin K are suggested for reducing cortisol, but their effectiveness is debated.
The conversation discusses concerns about the potential risk of cancer from creating new hairfollicles through microneedling, due to stemcell division. Specific treatments mentioned include microneedling, caffeine-containing anti-hair loss shampoos, and other unspecified topicals.
Adipose-derived stemcell secretome showed significant improvement in hair density and growth, especially when combined with minoxidil, suggesting a synergistic effect. The study had limitations, including a small sample size and potential bias.
PP405 is a new hair loss treatment in phase 2 trials that may promote hair growth by increasing lactate production and activating hairfolliclestem cells. It could potentially replace hormone-disrupting treatments like Minoxidil and finasteride.
PP405 is ineffective for miniaturized, fibrosed hairfollicles in androgenetic alopecia. AMP303 may activate hairfolliclestem cells, but minoxidil and finasteride are still the main treatments.