Role of ASLNC168501 in Regulating Hair Follicle Stem Cell Activity via the AR/miR-128-3p/IGF-1 Pathway

January 2026 in “ Stem Cell Research & Therapy ”

Xuewen Chen, Jingxiu Chai, Xuan Wang, Leimeng Gan, Qing Zhang, Hao Luo, Ling Wu, Yuchong Chen

ASLNC168501 androgenetic alopecia AR/miR-128-3p/IGF-1 pathway hair follicle stem cells IGF-1 miR-128-3p androgen receptor dermal papilla cells AGA HFSCs

TLDR ASLNC168501 can help treat hair loss by restoring hair follicle stem cell function.

This study identifies the AR/miR-128-3p/IGF-1 pathway as crucial in the dysfunction of hair follicle stem cells (HFSCs) in androgenetic alopecia (AGA). It finds that reduced IGF-1 expression impairs HFSCs activity, with AR activating miR-128-3p to suppress IGF-1. ASLNC168501, acting as a competing endogenous RNA, sequesters miR-128-3p, restoring IGF-1 levels. Overexpressing ASLNC168501 in dermal papilla cells enhances HFSCs' self-renewal and differentiation, reversing hair follicle atrophy in AGA mice, suggesting ASLNC168501 as a promising therapeutic target for AGA treatment.

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