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GlossaryHLA-DR

protein on immune cells presenting antigens to trigger responses

HLA-DR is a part of the human immune system, specifically a protein found on the surface of certain cells that helps the body distinguish between its own cells and foreign invaders. It plays a crucial role in the immune response by presenting pieces of proteins (antigens) to immune cells, which can then trigger an immune reaction. This protein is also involved in autoimmune conditions, where the immune system mistakenly attacks the body's own tissues.

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research Clinical and Genetic Aspects of Alopecia Areata: A Cutting Edge Review

1 citations , June 2023 in “Genes”

Hair loss from Alopecia Areata is caused by both genes and environment, with several treatments available but challenges in cost and relapse remain.

research Genome-wide association study in frontal fibrosing alopecia identifies four susceptibility loci including HLA-B*07:02

115 citations , March 2019 in “Nature Communications”

Frontal fibrosing alopecia is linked to four genetic areas, especially the HLA-B*07:02 allele.

Adrenal 21-Hydroxylase Gene Mutations in Slovenian Hyperandrogenic Women: Evaluation of Corticotrophin Stimulation and HLA Polymorphisms in Screening for Carrier Status

research Adrenal 21-hydroxylase gene mutations in Slovenian hyperandrogenic women: evaluation of corticotrophin stimulation and HLA polymorphisms in screening for carrier status

19 citations , August 1999 in “European journal of endocrinology”

The study concluded that testing hormone levels after stimulation is not reliable for identifying carriers of 21-hydroxylase deficiency; genetic testing is necessary.