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GlossaryHomocysteine

amino acid linked to cardiovascular risk and hair health

Homocysteine is an amino acid produced in the body during the metabolism of methionine, an essential amino acid found in many proteins. Elevated levels of homocysteine in the blood can be a risk factor for cardiovascular diseases and are also associated with conditions like alopecia, as high levels can damage blood vessels and affect hair follicle health.

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Research

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research Tyrosinase inhibition due to interaction of homocyst(e)ine with copper: the mechanism for reversible hypopigmentation in homocystinuria due to cystathionine beta-synthase deficiency.

74 citations , July 1995 in “PubMed”

Lowering homocyst(e)ine levels can reverse skin and hair lightening by restoring enzyme activity needed for pigmentation.

Enzyme Replacement Therapy Ameliorates Multiple Symptoms of Murine Homocystinuria

research Enzyme Replacement Therapy Ameliorates Multiple Symptoms of Murine Homocystinuria

29 citations , December 2017 in “Molecular therapy”

Enzyme replacement therapy improved multiple symptoms of homocystinuria in mice.

research Serum holotranscobalamine, vitamin B12, folic acid and homocysteine levels in alopecia areata patients

13 citations , May 2012 in “Cutaneous and ocular toxicology”

Alopecia areata is not linked to vitamin B12 deficiency.

research Homozygous whole body Cbs knockout in adult mice features minimal pathology during ageing despite severe homocysteinemia

7 citations , March 2022 in “The FASEB journal”

Adult mice with CBS deficiency show minimal health issues and normal lifespan despite high homocysteine levels.

research Mutations in Homocysteine Metabolism Genes Increase Keratin N-Homocysteinylation and Damage in Mice

5 citations , September 2018 in “International journal of genomics”

Genetic mutations that disrupt homocysteine breakdown lead to increased damage in mouse hair keratin.

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