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research Human stratum corneum proteomics reveals cross‐linking of a broad spectrum of proteins in cornified envelopes

44 citations , March 2019 in “Experimental Dermatology”

A wide range of proteins are integrated into the skin's protective layer.

research In vivo penetration of bare and lipid-coated silica nanoparticles across the human stratum corneum

16 citations , August 2014 in “Colloids and surfaces. B, Biointerfaces”

Lipid-coated silica nanoparticles penetrate human skin more deeply than bare silica nanoparticles.

research In vivo silica nanoparticle translocation across human stratum corneum: the effect of surface hydrophobization in relation to hair follicle density.

January 2013 in “IRIS UNIMORE (University of Modena and Reggio Emilia)”

Hydrophobized silica nanoparticles penetrate the skin's outer layer more effectively, while hair follicle density doesn't impact their accumulation.

research Trichohyalin: Presence in the Granular Layer and Stratum Corneum of Normal Human Epidermis

48 citations , May 1991 in “The journal of investigative dermatology/Journal of investigative dermatology”

Trichohyalin is also found in the outer layers of normal human skin.

research Relative uptake of minoxidil into appendages and stratum corneum and permeation through human skin in vitro

55 citations , June 2009 in “Journal of Pharmaceutical Sciences”

Minoxidil promotes hair growth by penetrating skin, with ethanol-containing formulas working best.

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community Peptides that Stop Hair Loss? | In-depth Literature Review Video

in Research/Science 74 upvotes 2 years ago

Peptides like TB500, KPV, GHK-CU, and BPC-157 are overhyped for hair growth with limited proven effectiveness in humans. Combining peptides with delivery methods like iontophoresis and sonophoresis shows promise, but many claims remain unproven.

community PP405 is NOT gray market jxl069

in Technology 26 upvotes 6 months ago

PP405 is a safer alternative to JXL069 for hair loss treatment because it penetrates the skin effectively and degrades in the blood, avoiding systemic toxicity. JXL069, when forced into the body, can cause dangerous side effects like lactic acidosis due to its inability to degrade safely.

community Topical tretinoin increases minoxidil absorption by 3x. Thoughts?

in Minoxidil 41 upvotes 7 years ago

Topical tretinoin can increase the absorption of minoxidil by three times, which may enhance its effectiveness for hair loss treatment. Tretinoin causes increased skin turnover, making the skin more permeable and potentially improving minoxidil's efficacy.

community DIY treatment... Shedding completely stopped after 1.5 yrs

in Treatment 246 upvotes 4 years ago

Vitamin C mixed with shampoo stopped shedding and promoted hair regrowth after 1.5 years. Both the person and their wife experienced significant hair loss reduction with this method.

community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

in Research 830 upvotes 2 years ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

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