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GlossaryHydrophilic

substance's ability to interact well with water

Hydrophilic refers to a substance's ability to interact well with water. These substances have a tendency to attract and hold water molecules due to their polar nature, which means they have regions with slight electrical charges that can form hydrogen bonds with water. This property is crucial in various biological processes, such as the behavior of proteins and the function of cell membranes.

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Research

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research Recent studies on the delivery of hydrophilic drugs in nanoparticulate systems

47 citations , September 2015 in “Journal of Drug Delivery Science and Technology”

Nanoparticulate systems improve drug delivery by controlling release, protecting drugs, changing absorption and distribution, and concentrating drugs in targeted areas.

research Distribution and Localization of Hydrophobic and Ionic Chemical Groups at the Surface of Bleached Human Hair Fibers

36 citations , October 2014 in “Langmuir”

Bleaching hair removes its protective top layer and exposes more hydrophilic groups, changing its chemical surface and affecting how it interacts with products.

research Emulgel: A Novel Approach For Hydrophobic Drugs

13 citations , April 2019 in “American Journal of PharmTech Research”

Emulgels effectively deliver hydrophobic drugs for skin conditions like acne and psoriasis.

research Core-shell nanocarriers based on PEGylated hydrophobic hyperbranched polyesters

7 citations , May 2016 in “European Polymer Journal”

The new nanocarriers improve how well water-insoluble drugs dissolve and allow for controlled drug release.

Changes in Hydrophobic Proteins in Response to Biotin Administration in Serum of Infant Patients with Alopecia as Assessed by the Protein Micro-Sequencing Method

research Changes in the Hydrophobic Proteins in Response to Biotin Administration in Serum of Infant Patients with Alopecia as Assessed by the Protein Micro-Sequencing Method

4 citations , January 2015 in “Journal of microbial & biochemical technology”

Biotin helps regulate proteins in the blood, which may explain its role in hair growth.

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community Hydrophobic Finasteride. Why don’t we have it?

in Chat 7 upvotes 1 year ago

The conversation discusses the potential benefits of creating a hydrophobic version of finasteride to reduce systemic side effects while maintaining scalp health. It compares this idea to fluridil, which is designed to be hydrophobic and has less systemic absorption.

community Why is dutasteride's volume of distribution so much bigger than finasteride? Is it more lipophilic and crosses barriers better?

in Finasteride/Dutasteride 24 upvotes 1 year ago

Dutasteride has a larger volume of distribution than finasteride due to its lipophilic nature, allowing it to concentrate in hydrophobic areas and making it difficult to excrete. A user experiencing hair loss has been using oral finasteride for 10 months with minimal regrowth and is considering switching to dutasteride or adding oral minoxidil.

community Stacking Fluridil / Topilutamide with other + aqueous topicals?

in Technology 1 upvotes 2 years ago

The conversation discusses how to use fluridil/topilutamide with other hair loss treatments like liquid minoxidil and CB-03-01, considering fluridil's hydrophobic nature and potential degradation with water. The user questions the necessity of washing hair only once per week as suggested by the manufacturer.

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