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5 / 1000+ resultsresearch Influence of particle parameters on deposition onto healthy and damaged human hair
This study examines how various particle parameters affect their deposition on healthy and damaged human hair. It was found that particles have a stronger affinity for healthy hair due to the intact lipid layer, while damaged hair, with more hydrophilic sites, shows more dispersed binding. Hydrophilic silica particles localize along the cuticle edges of healthy hair due to hydrogen bonding, whereas electrostatic attractions are more effective at lower particle concentrations. Larger particles deposit poorly compared to smaller ones, and positively charged particles show stronger affinity, with highly charged particles depositing most rapidly. The study highlights the influence of particle-surface interactions and the impact of hair damage on particle deposition.
research Recent studies on the delivery of hydrophilic drugs in nanoparticulate systems
Nanoparticulate systems improve drug delivery by controlling release, protecting drugs, changing absorption and distribution, and concentrating drugs in targeted areas.
research In vivo penetration of bare and lipid-coated silica nanoparticles across the human stratum corneum
Lipid-coated silica nanoparticles penetrate human skin more deeply than bare silica nanoparticles.
research Bioactive inorganic particles‐based biomaterials for skin tissue engineering
Bioactive inorganic particles-based biomaterials show promise for improving skin wound healing.
research Design of a biofluid-absorbing bioactive sandwich-structured Zn–Si bioceramic composite wound dressing for hair follicle regeneration and skin burn wound healing
Wound dressing absorbs fluid, regenerates hair follicles, and heals skin burns.
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5 / 1000+ resultscommunity Hydrophobic Finasteride. Why don’t we have it?
The conversation discusses the potential benefits of creating a hydrophobic version of finasteride to reduce systemic side effects while maintaining scalp health. It compares this idea to fluridil, which is designed to be hydrophobic and has less systemic absorption.
community Why is dutasteride's volume of distribution so much bigger than finasteride? Is it more lipophilic and crosses barriers better?
Dutasteride has a larger volume of distribution than finasteride due to its lipophilic nature, allowing it to concentrate in hydrophobic areas and making it difficult to excrete. A user experiencing hair loss has been using oral finasteride for 10 months with minimal regrowth and is considering switching to dutasteride or adding oral minoxidil.
community Stacking Fluridil / Topilutamide with other + aqueous topicals?
The conversation discusses how to use fluridil/topilutamide with other hair loss treatments like liquid minoxidil and CB-03-01, considering fluridil's hydrophobic nature and potential degradation with water. The user questions the necessity of washing hair only once per week as suggested by the manufacturer.
community Soundwaves & Electricity Grows Hair? | Peptide Delivery Model.
Iontophoresis and sonophoresis can enhance drug delivery into the scalp. Combining these methods may improve the effectiveness of topical treatments like dutasteride and certain peptides.
community Experiences with RU58841? Any results?
RU58841 is discussed for hair loss treatment, with mixed reviews on its effectiveness and side effects. Users mention using it in an ethanol/PG solution and combining it with other treatments like dutasteride.