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GlossaryHypertrophic Scars

raised, thickened skin areas from excessive collagen after injury

Hypertrophic scars are raised, thickened areas of skin that form at the site of an injury or incision. Unlike keloid scars, which can grow beyond the boundaries of the original wound, hypertrophic scars remain confined to the wound area but can be red, itchy, and sometimes painful. They result from an overproduction of collagen during the healing process and can improve over time, though treatments like silicone sheets, corticosteroid injections, or laser therapy may be used to reduce their appearance.

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research Combination of lyophilized adipose-derived stem cell concentrated conditioned medium and polysaccharide hydrogel in the inhibition of hypertrophic scarring

45 citations , January 2021 in “Stem Cell Research & Therapy”

The combination of stem cell medium and hydrogel effectively reduces and improves hypertrophic scars.

research Mesenchymal Stem Cells From Mouse Hair Follicles Reduce Hypertrophic Scarring in a Murine Wound Healing Model

13 citations , January 2022 in “Stem cell reviews and reports”

Mouse stem cells from hair follicles can improve wound healing and reduce scarring.

research The Secretome of Irradiated Peripheral Mononuclear Cells Attenuates Hypertrophic Skin Scarring

1 citations , March 2023 in “Pharmaceutics”

PBMCsec can help reduce and improve thick skin scars.

research Toward understanding scarless skin wound healing and pathological scarring

113 citations , June 2019 in “F1000Research”

Scarless healing is complex and influenced by genetics and environment, while better understanding could improve scar treatment.

research Treating Scars: Addressing Surface, Volume, and Movement to Expedite Optimal Results. Part 2: More-Severe Grades of Scarring

13 citations , June 2012 in “Dermatologic Surgery”

Severe scars need a mix of treatments for best results.

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community Verteporfin day 119 update - donor hair regeneration human trial

in Research/Science 146 upvotes 3 years ago

A human trial of verteporfin, a drug that can inhibit wound healing by scarring and promote regeneration of original tissue and hair follicles to provide an unlimited source for hair transplants; people discussed the potential of this drug and how it could be rolled out in mainstream with more doctors getting on board.

community Anyone else experiencing scalp inflammation? Get in here!

5 upvotes 7 years ago

A user found that taking Zyrtec (Cetirizine) and Advil helped reduce their scalp inflammation and pain, potentially creating a better environment for hair growth. They have not used any other medication for hair loss or scalp issues.

community DHT Harms Scalp Microbiome: DHT Itch is REAL

in Research/Science 416 upvotes 1 year ago

Increased Malassezia and Cutibacterium in the scalp microbiome are linked to higher sebum production and inflammation in androgenetic alopecia (AGA). Treatments include ciclopirox shampoo, benzoyl peroxide shampoo, clobetasol propionate, calcipotriol, minoxidil, finasteride, and dutasteride.

community 5% minoxidil &1mg finasteride -7th months- Asian-23M

in Progress Pictures 620 upvotes 2 years ago

A user's successful hair regrowth after 7 months of using 5% minoxidil, 1mg finasteride, and adding micro needling 4 months ago. The user also took biotin, fish oil, and collagen supplements, and reduced finasteride intake to once every 3 days due to minor libido decay.

community What's "wrong" with oral minoxidil, exactly?

in Minoxidil 173 upvotes 1 year ago

Oral minoxidil can boost hair growth but may cause side effects like heart palpitations and increased body hair. Many prefer topical minoxidil due to fewer side effects.

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