Combination of Lyophilized Adipose-Derived Stem Cell Concentrated Conditioned Medium and Polysaccharide Hydrogel in the Inhibition of Hypertrophic Scarring

    January 2021 in “ Stem Cell Research & Therapy ”
    Chaoyu Zhang, Ting Wang, Li Zhang, Penghong Chen, Shijie Tang, Aizhen Chen, Ming Li, Guohao Peng, Hangqi Gao, Haiyan Weng, Haoruo Zhang, Shirong Li, Jinghua Chen, Liangwan Chen, Xiaosong Chen
    TLDR The combination of stem cell medium and hydrogel effectively reduces and improves hypertrophic scars.
    The study examined the use of lyophilized adipose-derived stem cell concentrated conditioned medium (ADSCC-CM) combined with polysaccharide hydrogel to prevent hypertrophic scarring. Conducted on 12 male New Zealand rabbits, the research found that this combination, particularly the medium-dose ADSCC-CM with hydrogel (CM5+H), effectively reduced scar elevation and improved scar characteristics such as melanin, height, vascularity, and pliability. The ADSCC-CM downregulated α-smooth muscle actin (α-SMA) expression, indicating an anti-fibrosis effect, while the hydrogel served as a scaffold for sustained cytokine release. The study concluded that this combination could significantly enhance therapeutic outcomes in scar prevention, suggesting it as a promising strategy for hypertrophic scar prophylaxis.
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