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GlossaryHypogonadism

condition where sex glands produce insufficient hormones

Hypogonadism is a medical condition where the body's sex glands, the testes in men and the ovaries in women, produce little or no hormones. This can lead to various symptoms such as reduced libido, infertility, and in some cases, hair loss. It can be caused by genetic factors, injury, or certain medical conditions, and often requires hormone replacement therapy for management.

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research Original Research—Endocrinology: Comparison of the Steady-State Pharmacokinetics, Metabolism, and Variability of a Transdermal Testosterone Patch Versus a Transdermal Testosterone Gel in Hypogonadal Men

38 citations , February 2005 in “The journal of sexual medicine”

The testosterone patch and gel are both effective, but they have different absorption patterns and effects on hormone levels.

research The Five-Year Effects of Testosterone Replacement Therapy on Lipid Profile and Glucose Tolerance Among Hypogonadal Men in Japan: A Case Control Study

6 citations , January 2020 in “The Aging Male”

Testosterone replacement therapy improved blood sugar and fat levels without raising prostate cancer risk in Japanese men with low testosterone.

research Clinical Improvements in Erectile Function and Mood in Hypogonadal Men Treated with 4.5% Nasal Testosterone Gel (Natesto)

February 2018 in “The Journal of Sexual Medicine”

Natesto nasal gel improves erectile function and mood in men with low testosterone within 30 days.

research Cognitive Effects of Testosterone and Finasteride Administration in Older Hypogonadal Men

August 2014 in “DOAJ (DOAJ: Directory of Open Access Journals)”

Testosterone and finasteride showed minor cognitive benefits in older men.

research Oral Testosterone With and Without Concomitant Inhibition of 5α-Reductase by Dutasteride in Hypogonadal Men for 28 Days

11 citations , December 2010 in “The Journal of Urology”

Taking oral testosterone with or without dutasteride increases testosterone levels and could be an effective treatment for low testosterone.

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community Debunking the "Adverse metabolic consequences of dutasteride"

in Research/Science 42 upvotes 4 years ago

Dutasteride is more effective than finasteride, has neuroprotective benefits, and may prevent acne. Despite initial concerns about metabolic effects, further research suggests it is safe for most users, especially if not hypogonadal.

community Starting finasteride with poor hormones

in Finasteride/Dutasteride 7 upvotes 3 years ago

A user with low testosterone and mild gyno is considering finasteride for hair loss. Others suggest consulting an endocrinologist first and share experiences of finasteride not worsening gyno.

community Creatine is the opposite of minoxidil !

in Research/Science 327 upvotes 2 months ago

Creatine may counteract minoxidil's hair growth effects by closing potassium ATP channels, potentially leading to hair loss in predisposed individuals. Despite anecdotal reports, there is no conclusive evidence linking creatine to hair loss.

community 2.5mg Dut/RU/minoxidil can't counter 15mg Testosterone..

in Finasteride/Dutasteride 6 upvotes 10 months ago

Despite using Dutasteride, RU58841, and Minoxidil, hair loss continues due to low testosterone levels from taking 15mg of testosterone weekly, which may not produce enough estrogen. Increasing testosterone dosage and stabilizing hormone levels might help address the issue.

community Topical Dutasteride - Non-Hormonal, Side Effect Free 5ARI?

in Treatments 451 upvotes 1 year ago

Topical dutasteride is suggested as a low side-effect treatment for hair loss, with a proposed dose of 0.025% 1ml/day. It is considered better than finasteride due to its even inhibition of DHT isoforms and lower systemic absorption.

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