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GlossaryHypothalamic-Pituitary-Gonadal Axis

regulates reproductive hormones through interactions between brain and gonads

The Hypothalamic-Pituitary-Gonadal (HPG) Axis is a complex set of interactions among the hypothalamus, pituitary gland, and gonads (ovaries in females and testes in males) that regulate reproductive function and hormone production. This system controls the release of hormones like GnRH (gonadotropin-releasing hormone), LH (luteinizing hormone), and FSH (follicle-stimulating hormone), which are crucial for processes such as puberty, menstrual cycles, and sperm production.

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research Sex differences in the hypothalamic–pituitary–adrenal axis’ response to stress: an important role for gonadal hormones

197 citations , January 2019 in “Neuropsychopharmacology”

Male and female bodies respond differently to stress, influenced by hormones and development stages, with implications for stress-related diseases.

research Physiology of the Hypothalamic Pituitary Gonadal Axis in the Male

70 citations , March 2016 in “Urologic Clinics of North America”

The document explains how the male reproductive system works, its role in making testosterone, and how conditions like obesity can disrupt it, leading to low testosterone and fertility issues.

research Age-related changes in endogenous glucocorticoids, gonadal steroids, endocannabinoids and their ratios in plasma and hair from the male C57BL/6 mice

11 citations , October 2020 in “General and comparative endocrinology”

Male C57BL/6 mice show age-related fluctuations in certain hormones and their ratios in both blood and hair.

research Gonadal Sex Steroids: Production, Action and Interactions in Mammals

2 citations , November 2012 in “InTech eBooks”

The document concludes that sex hormones are crucial for mammalian reproduction, health, and behavior, and require more research for therapeutic use.

research Gonadal Function in Men with Cushing Syndrome

1 citations , November 2013

Men with low testosterone or breast growth should be checked for Cushing syndrome.

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community Ru, Stemoxydine or Alfatradiol? What has your experience been with any of these 3?

in Treatment 3 upvotes 3 years ago

The user is seeking advice on which treatment to add to their current regimen for male pattern baldness. They have previously tried Dutasteride, Nizoral, and oral Minoxidil, but experienced continued hair loss. They are specifically asking for experiences with RU58841, Stemoxydine, or Alfatradiol.

community Pyrilutamide: Increased libido. Anyone else experienced something similar with either RU or Pyri?

in Product 17 upvotes 3 years ago

An increase in libido associated with the use of Pyri, and a discussion about how it may be working comparably to other hair loss treatments such as RU58841, Finasteride and Minoxidil.

community Methods Of Staying Safe On Ru58841 - My 2 Cents

in Research/Science 21 upvotes 1 year ago

RU58841 is used topically to prevent hair loss by blocking DHT, with suggestions to drink grapefruit juice, take breaks, avoid microneedling, and use lower concentrations to reduce side effects. Users discuss applying it at night to minimize systemic absorption.

community Does the watery ejaculate issue ever resolve?

in Finasteride/Dutasteride 100 upvotes 5 months ago

Dutasteride and finasteride can cause watery ejaculate, which may persist for some users. Zinc supplements or switching to topical treatments are suggested to alleviate this side effect.

community This could be it!!! New treatment increase hair 500%

in Research/Science 343 upvotes 8 months ago

Clascoterone (Breezula) shows a potential 500% increase in hair growth, possibly outperforming minoxidil and finasteride. It is in advanced trials, with hopes for FDA approval, but cost and side effects are concerns.

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Hair Loss Treatments
Axis Stem Cell InstituteKirkland, WA · US

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