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GlossaryImmune Receptor

protein on immune cells that detects foreign substances

An immune receptor, also known as an immunoreceptor, is a protein found on the surface of immune cells, such as T cells and B cells. These receptors recognize and bind to specific antigens (foreign substances like bacteria or viruses), triggering an immune response to help the body fight off infections.

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Research

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Vasoactive Intestinal Peptide, Whose Receptor-Mediated Signaling May Be Defective in Alopecia Areata, Provides Protection from Hair Follicle Immune Privilege Collapse

research Vasoactive intestinal peptide, whose receptor-mediated signalling may be defective in alopecia areata, provides protection from hair follicle immune privilege collapse

36 citations , April 2016 in “British journal of dermatology/British journal of dermatology, Supplement”

A substance called VIP might protect hair follicles from being attacked by the immune system, and problems with VIP signaling could lead to hair loss in alopecia areata.

research Folate receptor β performs an immune checkpoint function in activated macrophages

1 citations , September 2025 in “Frontiers in Immunology”

Folate receptor β helps suppress the immune system in macrophages and affects cancer growth and hair health.

research 1338 Epidermal growth factor receptor protects from immune privilege collapse and scarring hair follicle destruction

April 2023 in “The journal of investigative dermatology/Journal of investigative dermatology”

Blocking EGFR can lead to hair loss due to inflammation and stem cell damage.

research Epidermal growth factor receptor/mitogen-activated kinase inhibitor treatment induces a distinct inflammatory hair follicle response that includes collapse of immune privilege

4 citations , June 2024 in “British Journal of Dermatology”

EGFRi/MEKi treatments cause hair follicles to lose some immune protection, leading to inflammation.

research Impact of epidermal growth factor receptor and mitogen-activated kinase inhibition on hair follicles (HFs): partial HF immune privilege collapse and excessive interleukin-33 secretion

1 citations , July 2024 in “British Journal of Dermatology”

Inhibiting certain proteins harms hair follicle immunity and increases IL-33, affecting hair health.

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Community Join

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community Why does MPB only affect the scalp

in Research/Science 14 upvotes 1 year ago

Male pattern baldness (MPB) may be influenced by androgen receptors in scalp hair follicles and potentially poor blood flow. Transplanted hair is not immune to DHT, and factors like inflammation and scalp tension might also contribute to hair loss.

community Prolactin's role in antitumor activity of the immune system - a safety concern for HMI-115?

in Research/Science 4 upvotes 3 years ago

Hair loss discussion includes treatments Minoxidil, Finasteride, and RU58841. Prolactin's role in immune system's antitumor activity raises safety concerns for HMI-115.

community My Theory Regarding a Cause and Cure for Androgenetic Alopecia

in Treatment 94 upvotes 6 years ago

Hair loss theory suggests imbalance between Vitamin D Receptor (VDR) and Androgen Receptor (AR) activation. Proposed treatment includes upregulating VDR, downregulating AR, and improving mitochondrial health.

community 21M with a nasty case of MPB; Heres what's on my radar for the future.

in Research/Science 16 upvotes 3 years ago

Hopeful treatments for hair loss, including Verteporfin, Androgen Receptor Degradation, and SCUBE3. These treatments offer potential solutions to slow or stop the effects of androgens on the scalp.

community Autoimmune issue?

in Question 2 upvotes 8 years ago

The user experienced severe hair loss, itchy scalp, and skin issues after trying no-shampoo, and wonders if it's male pattern baldness or an immune issue. They have a history of eczema, dermatitis, and jock itch, and have tried various treatments like coconut oil, peppermint, pumpkin seed, and onion.

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Learn

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learn Vitamin D

vitamin you should probably be taking for general health might also help your hair a little

learn Stem Cell Factor

learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

learn Neem Oil

natural substance from Neem tree with medicinal and pesticidal properties

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