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GlossaryInfundibulum

funnel-shaped upper part of a hair follicle

The infundibulum is the funnel-shaped upper part of a hair follicle, located just below the opening of the follicle at the skin's surface. It plays a crucial role in guiding the hair shaft as it grows and emerges from the skin, and it also serves as a pathway for sebum and other substances to reach the skin's surface.

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research The Changes in the Expression Levels of Follicular Markers in Keratoacanthoma Depend on the Stage: Keratoacanthoma Is a Follicular Neoplasm Exhibiting Infundibular/Isthmic Differentiation Without Expression of CK15

28 citations , February 2014 in “Journal of Cutaneous Pathology”

Keratoacanthoma changes as it grows, showing different hair follicle characteristics at each stage.

Infundibular Protein and RNA Microarray Analyses from Affected and Clinically Non-Affected Scalp in Male Androgenetic Alopecia Patients

research Infundibular Protein and RNA Microarray Analyses from Affected and Clinically Non-Affected Scalp in Male Androgenetic Alopecia Patients

8 citations , March 2017 in “Experimental Dermatology”

Finasteride helps female-pattern hair loss.

research Seborrheic Keratosis: A Tumor of the Infundibular and Isthmus of Hair Follicles - Identification of Hair Sheath Keratins and Histopathological Features Suggesting Hair Follicle Origin

2 citations , January 1989 in “The Nishinihon Journal of Dermatology”

Seborrheic keratosis likely originates from the upper regions of hair follicles.

Dermoscopy of Infundibular Keratinising Acanthomas and Follicular Cysts: Description, Assessment, and Histopathological Correlation

research Dermoscopy of Infundibular Keratinising Acanthomas and Follicular Cysts: Description, Assessment, and Histopathological Correlation

April 2025 in “Veterinary Dermatology”

Dermoscopy is useful for identifying skin lesions in dogs, with specific features distinguishing infundibular keratinising acanthomas from follicular cysts.

research Swiss Cheese Appearance of Dilated Follicular Infundibula in Trichotillomania

1 citations , January 2014 in “Indian Journal of Dermatology, Venereology and Leprology”

The 'Swiss cheese' pattern in scalp biopsies can indicate trichotillomania, not just alopecia areata.

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community I think I’ve finally found the reason for my hair loss

in Chat 98 upvotes 1 year ago

The user experienced hair loss since 2019 and tried finasteride, dutasteride, RU58841, and ketoconazole shampoo without success. A scalp biopsy showed scarring and inflammation from folliculitis, indicating chronic inflammation was affecting treatment effectiveness.

community Fibrosing alopecia in a pattern distribution

in Research/Science 14 upvotes 1 year ago

A user has been experiencing hair loss for 4 years, with treatments like minoxidil, finasteride, and various supplements proving ineffective. They were diagnosed with fibrosing alopecia in a pattern distribution, a condition that may require a combination of anti-inflammatory and hair growth treatments.

community The MPB itch aka DHT itch is very real.

in Chat 9 upvotes 2 years ago

Hair loss itch is caused by DHT attacking follicles and stimulating nerves. Finasteride users who respond well don't experience this itch.

community Is Finasteride the only way to reduce scalp DHT?

in Chat 28 upvotes 2 months ago

A 24-year-old male experienced side effects like low libido and ED after starting finasteride post-hair transplant and is seeking alternatives to reduce scalp DHT. Suggestions include topical finasteride, Xpecia, DHT-reducing shampoos, and switching to dutasteride, with some users reporting fewer side effects with these alternatives.

community Quote from Pelage (PP-405) Spokesperson...

in Research/Science 121 upvotes 2 months ago

Pelage is developing a topical hair follicle stem cell therapy, PP405, for non-scarring alopecias like androgenetic alopecia, with Phase III trials planned and a potential market launch by 2027. The treatment may not require continuous use after initial regrowth.

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