July 2025 in “Indian Dermatology Online Journal” A 45-year-old female with type-2 diabetes experienced trans-epidermal elimination (TEE) of insulin formulation, presenting as itchy lesions at injection sites. The condition was linked to a change in her isophane insulin brand, leading to a foreign body granulomatous reaction. Histopathology confirmed TEE, and treatment involved switching to oral diabetes medications, resolving the lesions. This case highlights the need to consider rare causes of perforating dermatoses beyond common ones, as insulin and its excipients can induce such reactions.
140 citations
,
December 2017 in “Journal of Controlled Release” Microneedles improve drug delivery in various body parts, are safe and painless, and show promise in cosmetology, vaccination, insulin delivery, and other medical applications.
3 citations
,
December 2023 in “International Journal of Nanomedicine” Repaglinide-loaded liponiosomal hybrids improve blood sugar control and insulin release better than regular Repaglinide.
August 2024 in “Majalah Obat Tradisional” Cayenne pepper microemulsion at 0.2% concentration significantly promotes hair growth.
22 citations
,
November 2023 in “Molecules” Smart microneedles can deliver drugs painlessly and accurately for diseases like diabetes and tumors.