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GlossaryInternal Standard

substance added to samples to ensure accurate measurements

An Internal Standard (IS) is a substance added in a constant amount to samples, calibrators, and quality controls in an analytical experiment. It is used to correct for variations in sample preparation and instrument response, ensuring more accurate and consistent results. This technique is particularly useful in fields like biochemistry and pharmacology, where precise quantification of compounds is critical.

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Quantitative Analysis of Finasteride Tablets Dissolution Content with Non-Isotopically Labeled Internal Standard by Paper Spray Ionization Mass Spectrometry

research Quantitative analysis of finasteride tablets dissolution content with non-isotopically labeled internal standard by paper spray ionization mass spectrometry

2 citations , September 2018 in “Journal of Separation Science”

PSI-MS quickly and accurately measures finasteride in tablets, helping with quality control.

research Targeted Determination of Residual Sex Hormones in Cosmetics Using Magnetic Solid-Phase Extraction with Isotope-Labeled Internal Standards by UHPLC-MS/MS

December 2025 in “Molecules”

A new method effectively detects trace sex hormones in cosmetics, ensuring safety.

research Matrix matching in quantitative bioanalysis by LC–MS/MS a dream or a reality?

2 citations , December 2019 in “Bioanalysis”

Accurate quantitative bioanalysis using LC-MS/MS is challenging due to matrix effects, but using internal standards and new methods like in-sample calibration could improve results.

research Simultaneous determination of multi-class active pharmaceutical ingredients by UHPLC-HRMS

2 citations , May 2021 in “Journal of pharmaceutical and biomedical analysis”

A new method was developed to accurately detect and measure 47 different drug ingredients in various products.

Ultra-Performance Liquid Chromatography with Electrospray Ionization Tandem Mass Spectrometry for the Determination of Ketoconazole in Anti-Dandruff Shampoo

research Ultra-Performance Liquid Chromatography with Electrospray Ionization Tandem Mass Spectrometry for the Determination of Ketoconazole in Anti-Dandruff Shampoo

1 citations , February 2014 in “Analytical Letters”

The method accurately measures the amount of ketoconazole in anti-dandruff shampoo and cream, and can also be used to monitor the drug in human plasma.

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community The Placebo Group Has It Worse Than The Standard Prescription 0.5mg Group. -The fear is all in your head.

in Finasteride/Dutasteride 187 upvotes 9 months ago

Dutasteride at 0.5mg may have fewer sexual side effects than expected, with many side effects attributed to psychological factors (nocebo effect). The placebo group experienced more side effects, suggesting fear and anxiety might contribute to perceived side effects.

community We already know how to permanently fix hair loss. The science is done. The only thing missing is the funding to run one experiment.

in Technology 613 upvotes 2 months ago

A permanent hair loss solution could involve reprogramming hair follicles to resist DHT using mRNA and siRNA. However, high costs, safety concerns, and the pharmaceutical industry's preference for ongoing treatments over one-time cures are major obstacles, with finasteride and minoxidil remaining standard treatments.

community 23M Seeking Advice on Finasteride/Dutasteride Concerns

in Basic Questions 144 upvotes 1 month ago

A 23-year-old is seeking advice on starting Finasteride for hair loss, questioning its effectiveness, side effects, and long-term safety, including concerns about dosage, alternatives, and potential impacts on fertility and beard growth. They also inquire about the effectiveness of combining topical and oral treatments and the necessity of Finasteride for maintaining hair transplant results.

community Scalp hydration's surprising link to hair growth cycle regulation

in Technology 23 upvotes 2 months ago

Scalp hydration may influence hair growth by affecting the signaling pathways that control the hair growth cycle. Users suggest using facial moisturizer, aloe vera, and oils for scalp hydration.

community Is there a consensus on RU these days? Pyril turned out to be a bust right?

in Research/Science 17 upvotes 2 years ago

The conversation discusses the effectiveness and safety of hair loss treatments, specifically RU58841 and Pyrilutimide (Pyril), with users sharing that Pyril was no more effective than a placebo and expressing concerns about the safety of RU58841 based on personal experiences and the lack of pharmaceutical interest.

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Learn

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learn Stem Cell Factor

learn Neem Oil

natural substance from Neem tree with medicinal and pesticidal properties

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