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research Cyclic ADP-Ribose Modulates Intracellular Calcium Homeostasis and Anagen-Associated Signaling Pathways in Human Hair Follicle Dermal Papilla Cells

January 2026 in “Applied Sciences”

Cyclic ADP-ribose helps regulate calcium and signals that promote hair growth in hair follicle cells.

Transcriptomic Analysis Reveals Candidate Ligand-Receptor Pairs and Signaling Networks Mediating Intercellular Communication between Hair Matrix Cells and Dermal Papilla Cells from Cashmere Goats

research Transcriptomic Analysis Reveals Candidate Ligand-Receptor Pairs and Signaling Networks Mediating Intercellular Communication between Hair Matrix Cells and Dermal Papilla Cells from Cashmere Goats

June 2023 in “Cells”

The research identified key molecules that help hair matrix and dermal papilla cells communicate and influence hair growth in cashmere goats.

research 1442 Neurotransmitter signaling specify sweat gland stem cell fate through intracellular calcium regulation

April 2023 in “Journal of Investigative Dermatology”

PRP can improve hair growth in people with hair loss, but more research is needed.

research The orchestrated network of skin photoaging: From intercellular crosstalk to molecular signaling

March 2026 in “BioScience Trends”

UV radiation causes skin aging by damaging cells and triggering harmful processes.

research Ku80 as a Novel Receptor for Thymosin β4 That Mediates Its Intracellular Activity Different from G-actin Sequestering

37 citations , November 2007 in “Journal of Biological Chemistry”

Ku80 is a key receptor for Thymosin β4, affecting cell migration and wound healing.

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community HLT Megathread on HMI-115 (key takeaways in comments)

in Research/Science 39 upvotes 3 years ago

HMI-115, a newly discovered hair loss treatment that could potentially be effective for those with diffuse thinning and telogen effluvium. It is based on prolactin receptor antagonist signaling and has already undergone Phase I trials in women, with potential commercialization by 2027.

community GT20029 and PP405 the new fin and min that we been waiting for ?

in Chat 36 upvotes 1 year ago

PP405 and GT20029 are new hair loss treatments with different mechanisms from traditional options like Minoxidil and Finasteride. PP405 targets hair follicle stem cells to reactivate growth, while GT20029 works as an androgen receptor deleter, both requiring ongoing use for effectiveness.

community The mechanism of androgenic alopecia

in Research/Science 34 upvotes 9 months ago

DHT may inhibit hair growth by affecting mitochondrial function, leading to hair follicle miniaturization. Treatments like minoxidil and PP405 may promote hair growth by altering metabolic pathways, potentially counteracting DHT's effects.

community Making your own RT1640 in China

in Research/Science 4 years ago

RT1640, a combination of cyclosporin A, minoxidil, and RT175, is discussed as a potential treatment for hair regrowth and repigmentation. The unique formulation aims to enhance hair follicle growth and restore hair pigment without the negative side effects of immunosuppressants.

community My derm said they came up with a new serum that is better then fin? What’s y’all’s thoughts

in Finasteride/Dutasteride 6 months ago

A new serum claims to enhance hair regrowth by amplifying oxygen delivery, improving the effectiveness of treatments like exosomes and peptides. Users are skeptical, questioning its efficacy compared to established treatments like Minoxidil and Finasteride.

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Learn

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learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

learn Epidermal Growth Factor

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