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GlossaryJAK3 Inhibitor

blocks an enzyme involved in immune response and inflammation

A JAK3 Inhibitor, also known as a Janus Kinase 3 Inhibitor, is a type of medication that blocks the activity of the JAK3 enzyme. This enzyme is involved in the signaling pathways that regulate immune responses and inflammation. By inhibiting JAK3, these drugs can help treat autoimmune diseases and conditions like alopecia areata, where the immune system mistakenly attacks hair follicles.

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Research

5 / 556 results

research Efficacy and safety of ritlecitinib, an oral JAK3/TEC family kinase inhibitor, in adolescent and adult patients with alopecia totalis and alopecia universalis

7 citations , September 2024 in “The Journal of Dermatology”

Ritlecitinib helps regrow hair in people with alopecia totalis and universalis and is safe to use.

Integrated Safety Analysis of Ritlecitinib, an Oral JAK3/TEC Family Kinase Inhibitor, for the Treatment of Alopecia Areata from the ALLEGRO Clinical Trial Program

research Integrated Safety Analysis of Ritlecitinib, an Oral JAK3/TEC Family Kinase Inhibitor, for the Treatment of Alopecia Areata from the ALLEGRO Clinical Trial Program

January 2024 in “American journal of clinical dermatology”

Ritlecitinib is safe and well-tolerated for treating alopecia areata in patients aged 12 and older.

research 801 TEC family kinase inhibitors as a novel class of therapeutics in alopecia areata

July 2024 in “Journal of Investigative Dermatology”

ITK inhibitors may effectively treat alopecia areata.

research 0935 Unravelling the role of JAK3/TEC kinase signalling with ritlecitinib in alopecia areata lesional skin and alopecia areata-induced human hair follicles ex vivo

July 2025 in “Journal of Investigative Dermatology”

Ritlecitinib reduces alopecia areata symptoms by blocking JAK3/TEC signaling and T-cell activity.

research 63418 JAK3/TEC kinase pathways are active in alopecia areata lesions, and their inhibition with Ritlecitinib prevents αCD3/αCD28+IL-2 induced immune privilege collapse in healthy hair follicles ex vivo

September 2025 in “Journal of the American Academy of Dermatology”

Ritlecitinib may help treat alopecia areata by protecting hair follicles.

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learn Tofacitinib

a JAK inhibitor for alopecia areata and other autoimmune conditions

learn Baricitinib

JAK inhibitor that reduces inflammation and immune attacks on hair follicles, leading to potential hair regrowth, especially in alopecia areata cases

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